Syringoma
| Syringoma | |
|---|---|
 | |
| Syringomas highlighted by white circles | |
| Specialty | Oncology  |
Syringomas are
Types
- The eruptive form typically presents on the anterior chest, abdomen, neck, and arms. It presents in successive crops with periods of relief in between times of active rash.
- The milia-like type of syringoma is typically smaller lesions that have a milky white center that can look like milia.
- The plaque type is more commonly associated with itchiness and chronic scratching that leads to epidermal thickening similar to lichen planus.
- The familial form, in some cases of syringoma, exhibits a familial pattern in an autosomal-dominant pattern of inheritance. Chromosome 16q22 has been shown to be involved in the genetic links of syringoma.
Presentation
Associated syndromes
Syringomas can be found in association with other symptoms as part of a syndrome. Hailey–Hailey disease (also known as familial benign chronic pemphigus) is a blistering disease that can also include syringomas.[5]
Several systemic syndromes have also been associated with syringoma including
Pathophysiology
The pathophysiology of syringomas remains largely unknown. Familial patterns presenting in an autosomal-dominant pattern suggest a genetic link that can result in varying genetic aberrations in lesions, specifically chromosome 16q22. The most commonly accepted theory is that syringomas are benign growths that arise from the intraepidermal portion of eccrine ducts. Another theory suggests that syringomas are a reactive
Diagnosis
Syringomas can often be diagnosed clinically based on presentation, distribution patterns over the body, lack of associated symptoms, and
Treatment
The goal of treatment is to improve the appearance of lesions, since they are otherwise not serious and typically do not cause symptoms. Many treatment methods have been attempted, but complete removal is uncommon. No single treatment method has been shown to work consistently. Both medical and surgical treatments have been studied, each with variable success. Common destructive treatment methods include
.The most common adverse effects include redness, skin discoloration, and pain. Other side effects include blistering and scarring.
See also
- Acrospiroma
- List of cutaneous conditions
- List of cutaneous neoplasms associated with systemic syndromes
References
- ISBN 0-7216-2921-0.
- ^ "Skin lesions, tumours and cancers. DermNet NZ". www.dermnetnz.org. Retrieved 2015-11-15.
- S2CID 40892331. Archived from the original(PDF) on 2019-02-24.
- ^ "Syringoma. DermNet NZ". www.dermnetnz.org. Retrieved 2015-11-15.
- ^ "Hailey-Hailey disease (benign familial pemphigus). DermNet NZ". www.dermnetnz.org. Retrieved 2015-11-15.
External links