Dosage form

Source: Wikipedia, the free encyclopedia.

Dosage forms (also called unit doses) are pharmaceutical drug products in the form in which they are marketed for use, with a specific mixture of active ingredients and inactive components (excipients), in a particular configuration (such as a capsule shell, for example), and apportioned into a particular dose. For example, two products may both be amoxicillin, but one is in 500 mg capsules and another is in 250 mg chewable tablets. The term unit dose can also sometimes encompass non-reusable packaging as well (especially when each drug product is individually packaged[1]), although the FDA distinguishes that by unit-dose "packaging" or "dispensing".[2] Depending on the context, multi(ple) unit dose can refer to distinct drug products packaged together, or to a single drug product containing multiple drugs and/or doses. The term dosage form can also sometimes refer only to the pharmaceutical formulation of a drug product's constituent drug substance(s) and any blends involved, without considering matters beyond that (like how it is ultimately configured as a consumable product such as a capsule, patch, etc.). Because of the somewhat vague boundaries and unclear overlap of these terms and certain variants and qualifiers within the pharmaceutical industry, caution is often advisable when conversing with someone who may be unfamiliar with another person's use of the term.

Depending on the method/route of administration, dosage forms come in several types. These include many kinds of liquid, solid, and semisolid dosage forms. Common dosage forms include

pill, tablet, or capsule, drink or syrup
, among many others.

When one drug product (for example, one tablet, one capsule, one syrup) contains more than one drug (more than one active ingredient), that product is a combination drug (fixed-dose combination; FDC).

In naturopathy, dosages can take the form of decoctions and herbal teas, as well as the more conventional methods previously mentioned.

The

blood stream, and is thereby incapable of sufficiently reaching its therapeutic target destinations. The oral and intravenous doses of a drug such as paracetamol will differ for the same reason.[3]

Oral

Tablet in blister pack
single unit packets with full identification (text and bar codes)

Ophthalmic

vials of eye drops for single use
  • Eye drops
  • Lotions
  • Ointments
  • Emulsions

Inhalation

Unintended ingredients

Talc is an

cut with cheap talc. Natural talc is cheap but contains asbestos while asbestos-free talc is more expensive. Inhaled talc that has asbestos is generally accepted as being able to cause lung cancer if it is inhaled. The evidence about asbestos-free talc is less clear, according to the American Cancer Society.[4]

Injection

An ampoule containing atropine injection 1mL/0.5mg

Parenteral

  • Intradermally
    -administered (ID)
  • Subcutaneously
    -administered (SC)
  • Intramuscularly
    -administered (IM)
  • Intraosseous
    administration (IO)
  • Intraperitoneally
    -administered (IP)
  • intravenously
    -administered (IV)
  • Intracavernously-administered (ICI)

These are usually solutions and suspensions.

Unintended ingredients

Safe

needle exchange programs.[citation needed
]

Unsafe

The injection of talc from crushed pills has been associated with pulmonary talcosis in intravenous drug users.[5]

Topical

Unintended use

  • It is not safe to calculate divided doses by cutting and weighing medical skin patches, because there's no guarantee that the substance is evenly distributed on the patch surface.[6] For example, fentanyl transdermal patches are designed to slowly release the substance over 3 days. It is well known that cut fentanyl transdermal consumed orally have cause overdoses and deaths.
  • Single blotting papers for illicit drugs injected from solvents in syringes may also cause uneven distribution across the surface.

Other

See also

References

  1. ^ "unit dose". thefreedictionary.com.
  2. ^ Affairs, Office of Regulatory. "Compliance Policy Guides - CPG Sec 430.100 Unit Dose Labeling for Solid and Liquid Oral Dosage Forms". www.fda.gov.
  3. ^ "Doctors 'missed' fatal overdoses". 4 February 2011 – via www.bbc.co.uk.
  4. ^ "Talcum Powder and Cancer". www.cancer.org.
  5. PMID 6655726
    .
  6. . Retrieved 17 May 2022.

External links