LATS2
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Large tumor suppressor kinase 2 (LATS2) is an enzyme that in humans is encoded by the LATS2 gene.[5][6]
This gene encodes a
androgen-responsive gene expression.[6]
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000150457 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000021959 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- PMID 10673337.
- ^ a b "Entrez Gene: LATS2 LATS, large tumor suppressor, homolog 2 (Drosophila)".
Further reading
- Hori T, Takaori-Kondo A, Kamikubo Y, Uchiyama T (2000). "Molecular cloning of a novel human protein kinase, kpm, that is homologous to warts/lats, a Drosophila tumor suppressor". Oncogene. 19 (27): 3101–9. PMID 10871863.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. PMID 12477932.
- Li Y, Pei J, Xia H, et al. (2003). "Lats2, a putative tumor suppressor, inhibits G1/S transition". Oncogene. 22 (28): 4398–405. PMID 12853976.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. PMID 14702039.
- Powzaniuk M, McElwee-Witmer S, Vogel RL, et al. (2005). "The LATS2/KPM tumor suppressor is a negative regulator of the androgen receptor". Mol. Endocrinol. 18 (8): 2011–23. PMID 15131260.
- Toji S, Yabuta N, Hosomi T, et al. (2005). "The centrosomal protein Lats2 is a phosphorylation target of Aurora-A kinase". Genes Cells. 9 (5): 383–97. PMID 15147269.
- Ke H, Pei J, Ni Z, et al. (2004). "Putative tumor suppressor Lats2 induces apoptosis through downregulation of Bcl-2 and Bcl-x(L)". Exp. Cell Res. 298 (2): 329–38. PMID 15265683.
- Chan EH, Nousiainen M, Chalamalasetty RB, et al. (2005). "The Ste20-like kinase Mst2 activates the human large tumor suppressor kinase Lats1". Oncogene. 24 (12): 2076–86. S2CID 27285160.
- Takahashi Y, Miyoshi Y, Takahata C, et al. (2005). "Down-regulation of LATS1 and LATS2 mRNA expression by promoter hypermethylation and its association with biologically aggressive phenotype in human breast cancers". Clin. Cancer Res. 11 (4): 1380–5. PMID 15746036.
- Abe Y, Ohsugi M, Haraguchi K, et al. (2006). "LATS2-Ajuba complex regulates gamma-tubulin recruitment to centrosomes and spindle organization during mitosis". FEBS Lett. 580 (3): 782–8. PMID 16413547.
- Voorhoeve PM, le Sage C, Schrier M, et al. (2006). "A genetic screen implicates miRNA-372 and miRNA-373 as oncogenes in testicular germ cell tumors". Cell. 124 (6): 1169–81. PMID 16564011.
- Aylon Y, Michael D, Shmueli A, et al. (2007). "A positive feedback loop between the p53 and Lats2 tumor suppressors prevents tetraploidization". Genes Dev. 20 (19): 2687–700. PMID 17015431.
- Jiang Z, Li X, Hu J, et al. (2007). "Promoter hypermethylation-mediated down-regulation of LATS1 and LATS2 in human astrocytoma". Neurosci. Res. 56 (4): 450–8. S2CID 22763208.
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