MAPK13
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Mitogen-activated protein kinase 13 (MAPK 13), also known as stress-activated protein kinase 4 (SAPK4), is an enzyme that in humans is encoded by the MAPK13 gene.[5]
Function
The protein encoded by this gene is a member of the
substrates of this kinase.[5]
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000156711 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000004864 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ a b "Entrez Gene: mitogen-activated protein kinase 13".
Further reading
- Efimova T, Broome AM, Eckert RL (2004). "Protein kinase Cdelta regulates keratinocyte death and survival by regulating activity and subcellular localization of a p38delta-extracellular signal-regulated kinase 1/2 complex". Mol. Cell. Biol. 24 (18): 8167–83. PMID 15340077.
- Joneson T, Bar-Sagi D (1997). "Ras effectors and their role in mitogenesis and oncogenesis". J. Mol. Med. 75 (8): 587–93. S2CID 23541383.
- Efimova T (2010). "p38delta mitogen-activated protein kinase regulates skin homeostasis and tumorigenesis". Cell Cycle. 9 (3): 498–05. PMID 20090411.
- Gutierrez-Sanmartin D, Varela-Ledo E, Aguilera A, et al. (2008). "Implication of p38 mitogen-activated protein kinase isoforms (alpha, beta, gamma and delta) in CD4+ T-cell infection with human immunodeficiency virus type I." J. Gen. Virol. 89 (Pt 7): 1661–71. PMID 18559936.
- Zhang J, Harrison JS, Studzinski GP (2011). "Isoforms of p38MAPK gamma and delta contribute to differentiation of human AML cells induced by 1,25-dihydroxyvitamin D₃". Exp. Cell Res. 317 (1): 117–30. PMID 20804750.
- Segat L, Brandão LA, Guimarães RL, et al. (2010). "Polymorphisms in innate immunity genes and patients response to dendritic cell-based HIV immuno-treatment". Vaccine. 28 (10): 2201–6. PMID 20056178.
- Zhou X, Ferraris JD, Dmitrieva NI, et al. (2008). "MKP-1 inhibits high NaCl-induced activation of p38 but does not inhibit the activation of TonEBP/OREBP: opposite roles of p38alpha and p38delta". Proc. Natl. Acad. Sci. U.S.A. 105 (14): 5620–5. PMID 18367666.
- Coulthard LR, Taylor JC, Eyre S, et al. (2011). "Genetic variants within the MAP kinase signalling network and anti-TNF treatment response in rheumatoid arthritis patients". Ann. Rheum. Dis. 70 (1): 98–103. S2CID 37511360.
- Efimova T, Broome AM, Eckert RL (2003). "A regulatory role for p38 delta MAPK in keratinocyte differentiation. Evidence for p38 delta-ERK1/2 complex formation". J. Biol. Chem. 278 (36): 34277–85. PMID 12810719.
- Kim SJ, Zhang Z, Hitomi E, et al. (2006). "Endoplasmic reticulum stress-induced caspase-4 activation mediates apoptosis and neurodegeneration in INCL". Hum. Mol. Genet. 15 (11): 1826–34. PMID 16644870.
- Talmud PJ, Drenos F, Shah S, et al. (2009). "Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip". Am. J. Hum. Genet. 85 (5): 628–42. PMID 19913121.
- Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. PMID 14574404.
- Colland F, Jacq X, Trouplin V, et al. (2004). "Functional proteomics mapping of a human signaling pathway". Genome Res. 14 (7): 1324–32. PMID 15231748.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. PMID 15489334.
- Ozawa S, Ito S, Kato Y, et al. (2010). "Human p38 delta MAP kinase mediates UV irradiation induced up-regulation of the gene expression of chemokine BRAK/CXCL14". Biochem. Biophys. Res. Commun. 396 (4): 1060–4. PMID 20478268.
- Kitatani K, Sheldon K, Anelli V, et al. (2009). "Acid beta-glucosidase 1 counteracts p38delta-dependent induction of interleukin-6: possible role for ceramide as an anti-inflammatory lipid". J. Biol. Chem. 284 (19): 12979–88. PMID 19279008.
- Tan FL, Ooi A, Huang D, et al. (2010). "p38delta/MAPK13 as a diagnostic marker for cholangiocarcinoma and its involvement in cell motility and invasion". Int. J. Cancer. 126 (10): 2353–61. S2CID 34276751.
- Sofroniew MV, Howe CL, PMID 11520933.
- Bailey SD, Xie C, Do R, et al. (2010). "Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study". Diabetes Care. 33 (10): 2250–3. PMID 20628086.
- Sumara G, Formentini I, Collins S, et al. (2009). "Regulation of PKD by the MAPK p38delta in insulin secretion and glucose homeostasis". Cell. 136 (2): 235–48. PMID 19135240.
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