Mitogen-activated protein kinase 9
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Mitogen-activated protein kinase 9 is an enzyme that in humans is encoded by the MAPK9 gene.[5]
Function
The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase targets specific transcription factors, and thus mediates immediate-early gene expression in response to various cell stimuli. It is most closely related to MAPK8, both of which are involved in UV radiation-induced apoptosis, thought to be related to the cytochrome c-mediated cell death pathway. This gene and MAPK8 are also known as c-Jun N-terminal kinases. This kinase blocks the ubiquitination of tumor suppressor p53, and thus it increases the stability of p53 in nonstressed cells. Studies of this gene's mouse counterpart suggest a key role in T-cell differentiation. Four alternatively spliced transcript variants encoding distinct isoforms have been reported.[6]
Interactions
Mitogen-activated protein kinase 9 has been shown to
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000050748 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000020366 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- PMID 8001819.
- ^ "Entrez Gene: MAPK9 mitogen-activated protein kinase 9".
- PMID 9019171.
- PMID 7642542.
- ^ PMID 10490659.
- PMID 9733513.
- PMID 10523642.
- PMID 10629060.
- PMID 9393873.
- PMID 12384512.
- PMID 12151396.
Further reading
- Lin A (2006). "The JNK Signaling Pathway (Molecular Biology Intelligence Unit)". Landes Bioscience. 1: 1–97. ISBN 978-1587061202.
- Davis RJ (2000). "Signal transduction by the JNK group of MAP kinases". Cell. 103 (2): 239–52. S2CID 343677.
- Liu J, Lin A (2007). "Wiring the cell signaling circuitry by the NF-kappa B and JNK1 crosstalk and its applications in human diseases". Oncogene. 26 (22): 3267–78. S2CID 28428831.
External links
- MAP Kinase Resource Archived 2021-04-15 at the Wayback Machine.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.