NUAK1
| NUAK1 | |||
|---|---|---|---|
| Identifiers | |||
Gene ontology | |||
| Molecular function | |||
| Cellular component | |||
| Biological process |
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| Sources:Amigo / QuickGO | |||
Ensembl | |||||||||
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| UniProt | |||||||||
| RefSeq (mRNA) | |||||||||
| RefSeq (protein) | |||||||||
| Location (UCSC) | Chr 12: 106.06 – 106.14 Mb | Chr 10: 84.21 – 84.28 Mb | |||||||
| PubMed search | [3] | [4] | |||||||
| View/Edit Human | View/Edit Mouse |
NUAK family SNF1-like kinase 1 also known as AMPK-related protein kinase 5 (ARK5) is an enzyme that in humans is encoded by the NUAK1 gene.[5][6][7]
Function
Acts as a regulator of cellular senescence and cellular ploidy by mediating phosphorylation of 'Ser-464' of LATS1, thereby controlling its stability. Controls cell adhesion by regulating activity of the myosin protein phosphatase 1 (PP1) complex.[8]
Clinical significance
ARK5 is important in tumor malignancy and invasiveness.[9]
Research findings
ARK5 is often overexpressed in multiple myeloma cell lines.[10][11] ARK5 promotes tumor cell survival under regulation by
Akt.[9]
ARK5 increases
MMP-9 which are involved in tumor metastasis.[9]
)
As a drug target
CDK4 inhibitor), also inhibits ARK5 and reduces proliferation of multiple myeloma and mantle cell lymphoma cell lines.[10]
Interactions
NUAK1 has been shown to
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000074590 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000020032 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- S2CID 23605132.
- S2CID 20975883.
- ^ "Entrez Gene: NUAK1 NUAK family, SNF1-like kinase, 1".
- ^ Protein Coding (2021-11-14). "NUAK1 Gene - NUAK Family Kinase 1". Gene Cards. Retrieved 2021-12-19.
- ^ PMID 15060171.
- ^ a b Multi-Target Drug Blocks Myeloma Proliferation. March 2016
- .
- ^ S2CID 13038944.
Further reading
- Nagase T, Ishikawa K, Miyajima N, et al. (1998). "Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Res. 5 (1): 31–9. PMID 9628581.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. PMID 14702039.
- Lizcano JM, Göransson O, Toth R, et al. (2005). "LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1". EMBO J. 23 (4): 833–43. PMID 14976552.
- Suzuki A, Kusakai G, Kishimoto A, et al. (2004). "Regulation of caspase-6 and FLIP by the AMPK family member ARK5". Oncogene. 23 (42): 7067–75. S2CID 13635036.
- Kusakai G, Suzuki A, Ogura T, et al. (2005). "Strong association of ARK5 with tumor invasion and metastasis". J. Exp. Clin. Cancer Res. 23 (2): 263–8. PMID 15354411.
- Suzuki A, Iida S, Kato-Uranishi M, et al. (2006). "ARK5 is transcriptionally regulated by the Large-MAF family and mediates IGF-1-induced cell invasion in multiple myeloma: ARK5 as a new molecular determinant of malignant multiple myeloma". Oncogene. 24 (46): 6936–44. PMID 16044163.
- Al-Hakim AK, Göransson O, Deak M, et al. (2006). "14-3-3 cooperates with LKB1 to regulate the activity and localization of QSK and SIK". J. Cell Sci. 118 (Pt 23): 5661–73. S2CID 17404931.
- Suzuki A, Ogura T, Esumi H (2006). "NDR2 acts as the upstream kinase of ARK5 during insulin-like growth factor-1 signaling". J. Biol. Chem. 281 (20): 13915–21. PMID 16488889.
- Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. PMID 17353931.
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