Polo kinase
| Polo kinase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
In
enzymology, a polo kinase (EC 2.7.11.21) is a kinase enzyme i.e. one that catalyzes the chemical reaction
- ATP + a protein ADP + a phosphoprotein
Thus, the two
substrates of these enzymes are ATP and protein, whereas their two products are ADP and phosphoprotein
.
These enzymes belong to the family of
protein-serine/threonine kinases
).
The systematic name of this [polo[-like] kinase] enzyme class is ATP:protein phosphotransferase (spindle-pole-dependent).
Examples and other names in common use include Cdc5, Cdc5p, Plk, PLK, Plk1, Plo1, POLO kinase, polo serine-threonine kinase, polo-like kinase, polo-like kinase 1, serine/threonine-specific Drosophila kinase polo, and STK21.
These enzymes participate in 3 metabolic pathways: cell cycle, cell cycle - yeast, and progesterone-mediated oocyte maturation.
Structural studies
As of late 2007, 5
structures have been solved for this class of enzymes, with PDB accession codes 2OGQ, 2OJS, 2OJX, 2OU7, and 2OWB
.
References
- Llamazares, Moreira, Tavares, et al. (1991). "polo encodes a protein kinase homolog required for mitosis in Drosophila". Genes Dev. 5 (12A): 2153–65. PMID 1660828.
- "Identification and cloning of a protein kinase-encoding mouse gene, Plk, related to the polo gene of Drosophila" 1993
- Golsteyn RM, Mundt KE, Fry AM, Nigg EA (1995). "Cell cycle regulation of the activity and subcellular localization of Plk1, a human protein kinase implicated in mitotic spindle function". J. Cell Biol. 129 (6): 1617–28. PMID 7790358.
- Mulvihill DP, Hyams JS (2002). "Cytokinetic actomyosin ring formation and septation in fission yeast are dependent on the full recruitment of the polo-like kinase Plo1 to the spindle pole body and a functional spindle assembly checkpoint". J. Cell Sci. 115 (Pt 18): 3575–86. PMID 12186944.
- Ohkura H (2003). "Phosphorylation: polo kinase joins an elite club". Curr. Biol. 13 (23): R912–4. S2CID 12000886.
