MAPK15
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| Location (UCSC) | Chr 8: 143.72 – 143.72 Mb | Chr 15: 75.87 – 75.87 Mb | |||||||
| PubMed search | [3] | [4] | |||||||
| View/Edit Human | View/Edit Mouse |
Mitogen-activated protein kinase 15, also known as MAPK15, ERK7, or ERK8, is an enzyme that in humans is encoded by the MAPK15 gene.[5][6]
Evolutionarily, MAPK15 is conserved in a number of species, including
Function
The protein encoded by this gene is a member of the
In vertebrate models, ERK8 is not constitutively active, and exhibits relatively low basal kinase activity.
Specifically, MAPK15 expression is significantly reduced in human lung and breast
Interactions
MAPK15 has been demonstrated to interact with gamma-aminobutyric acid receptor-associated protein (GABARAP) and microtubule-associated proteins 1A/1B light chain 3A (MAP1LC3A, or LC3) in a process that stimulates autophagy.[11] A number of additional proteins also interact with MAPK15, including cyclin-dependent kinase 2 (CDK2), mitogen-activated protein kinase 12 (MAPK12), and lactotransferrin (LTF), among many others.[6]
Clinical significance
Due to its role in protecting genomic integrity and cell motility, MAPK15 has been identified as a potential target for cancer therapeutics.
References
- ^ a b c ENSG00000274205 GRCh38: Ensembl release 89: ENSG00000181085, ENSG00000274205 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000063704 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ PMID 11875070.
- ^ a b c "Entrez Gene: MAPK15 mitogen-activated protein kinase 15".
- ^ PMID 24618899.
- PMID 21190936.
- PMID 20733054.
- PMID 25823377.
- PMID 22948227.
- PMID 23326322.
Further reading
- Saelzler MP, Spackman CC, Liu Y, Martinez LC, Harris JP, Abe MK (Jun 2006). "ERK8 down-regulates transactivation of the glucocorticoid receptor through Hic-5". The Journal of Biological Chemistry. 281 (24): 16821–32. PMID 16624805.
- Iavarone C, Acunzo M, Carlomagno F, Catania A, Melillo RM, Carlomagno SM, Santoro M, Chiariello M (Apr 2006). "Activation of the Erk8 mitogen-activated protein (MAP) kinase by RET/PTC3, a constitutively active form of the RET proto-oncogene" (PDF). The Journal of Biological Chemistry. 281 (15): 10567–76. S2CID 45690153.
- Klevernic IV, Stafford MJ, Morrice N, Peggie M, Morton S, Cohen P (Feb 2006). "Characterization of the reversible phosphorylation and activation of ERK8". The Biochemical Journal. 394 (Pt 1): 365–73. PMID 16336213.
- Suzuki Y, Yamashita R, Shirota M, Sakakibara Y, Chiba J, Mizushima-Sugano J, Nakai K, Sugano S (Sep 2004). "Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions". Genome Research. 14 (9): 1711–8. PMID 15342556.
- Kinet S, Bernard F, Mongellaz C, Perreau M, Goldman FD, Taylor N (Oct 2002). "gp120-mediated induction of the MAPK cascade is dependent on the activation state of CD4(+) lymphocytes". Blood. 100 (7): 2546–53. PMID 12239168.
- Qian Z, Okuhara D, Abe MK, Rosner MR (Jan 1999). "Molecular cloning and characterization of a mitogen-activated protein kinase-associated intracellular chloride channel". The Journal of Biological Chemistry. 274 (3): 1621–7. PMID 9880541.
External links
- MAP Kinase Resource Archived 2021-04-15 at the Wayback Machine
