Irwin Rose

Source: Wikipedia, the free encyclopedia.
Irwin Rose
protein degradation
SpouseZelda Budenstein[1]
Children4[1]
AwardsNobel Prize in Chemistry (2004)
Scientific career
FieldsBiology
Institutions
ThesisStudies on the Biochemical Synthesis of Nucleic Acids (1952)
Doctoral advisorBernard S. Schweigert

Irwin Allan Rose (July 16, 1926 – June 2, 2015) was an American

protein degradation.[2][1][3]

Education and early life

Rose was born in

NYU.[4]

Career and research

Rose served on the faculty of Yale School of Medicine's department of biochemistry from 1954 to 1963. He then joined the Fox Chase Cancer Center in 1963 and stayed there until he retired in 1995.[6] He joined University of Pennsylvania during the 1970s and served as a Professor of Physical Biochemistry.[7] He was a distinguished professor-in-residence in the Department of Physiology and Biophysics at the University of California, Irvine School of Medicine at the time his Nobel Prize was announced in 2004.[6]

Irwin (Ernie) trained several

postdoctoral research fellows while at the Fox Chase Cancer Center in Philadelphia. These included Art Haas,[8] the first to see Ubiquitin chains, Keith Wilkinson,[2] the one to first identify APF-1 as Ubiquitin, and Cecile Pickart.[9]

Published work

When Irwin Rose started on his prizewinning work on ubiquitin he was already very distinguished as an enzymologist.

Classical enzymology

Only a selection of Rose's very extensive work in this field is mentioned here.

In collaboration with Marianne Grunberg-Manago, Saul Korey and Severo Ochoa he investigated the Mg2+- or Mn2+-dependent formation of acetyl-CoA from acetate and ATP catalyzed by acetate kinase, an essential reaction for priming the tricarboxylate cycle,[10][11] describing the purification of the enzyme and measuring the equilibrium constant of the reaction.

With Edward O'Connell, Rose investigated the mechanisms of the reaction catalyzed by phosphoglucose isomerase[12] and, with Sidney Rieder, of triose phosphate isomerase[13]

With Jessie Warms, he studied the mechanism of hexokinase of sarcoma tumor,[14] finding that it was located in the mitochondria of liver and brain, and bound in accord with a Mg2+-dependent equilibrium.

He had a general interest in the role of magnesium in cells, and studied it on the basis of the equilibrium of the reaction catalyzed by adenylate kinase,[15] a complicated question, because numerous complexes of Mg2+, H+ and K+ with ATP, ADP and AMP need to be taken into account.

Starting from Ogston's theory, Rose[16] was concerned with the stereochemistry of enzyme-catalysed reactions, investigating various enzymes,[17] and later glutamine synthetase.[18] This was the topic of a review article written with Kenneth Hanson.[19]

Ubiquitin

After its discovery by Gideon Goldstein and colleagues in 1975,[20] ubiquitin was extensively studied by Rose, with Avram Hershko, Aaron Ciechanover, A. L. Haas and H. Heller,[21] one of many papers on the subject.

Awards and honors

Rose was awarded the Nobel prize in 2004.[4][22]

Personal life

Rose was married to Zelda Budenstein and had four children.[5] He died on June 2, 2015, at Deerfield, Massachusetts.[5][23] His widow died in 2016.

See also

References

  1. ^
    PMID 16094392
    .
  2. ^
    PMID 26223618
    .
  3. PMID 290989
    .
  4. ^ a b c Irwin Rose on Nobelprize.org Edit this at Wikidata including the Nobel Lecture on December 8, 2004 Ubiquitin at Fox Chase
  5. ^ a b c Chang, Kenneth (2 June 2015). "Irwin A. Rose, Nobel-Winning Biochemist, Dies at 88". New York Times. Retrieved 4 June 2015.
  6. ^ a b Weil, Martin (3 June 2015). "Irwin Rose, who shared 2004 Nobel Prize in chemistry, dies at 88". Washington Post. Retrieved 4 June 2015.
  7. ^ "Selected Awards and Honors to Penn Faculty and Alumni: Nobel Prizes". University of Pennsylvania Website. Archived from the original on 3 November 2013. Retrieved 4 June 2015.
  8. PMID 6990414
    .
  9. S2CID 177309829
  10. PMID 13221579
    .
  11. ISBN 9780121818012
    .
  12. PMID 14493830
    .
  13. PMID 13654309
    .
  14. PMID 4225734
    .
  15. PMID 5246543
    .
  16. PMID 14082366
    .
  17. PMID 5484463
    .
  18. PMID 9406
    .
  19. doi:10.1021/ar50085a001
    .
  20. PMID 1078892
    .
  21. PMID 6990414
    .
  22. PMID 15483574
  23. ^ ABC News. "2004 Nobel Chemistry Winner Irwin Rose Dies at 88". ABC News.

External links

  • Irwin Rose on Nobelprize.org Edit this at Wikidata including the Nobel Lecture on December 8, 2004 Ubiquitin at Fox Chase
Wikimedia Commons has media related to Irwin Rose.
Retrieved from "https://en.wikipedia.org/w/index.php?title=Irwin_Rose&oldid=1219222909"