Brian Kobilka
Brian Kobilka | |
---|---|
Born | Brian Kent Kobilka May 30, 1955 Little Falls, Minnesota, United States |
Nationality | American |
Alma mater | University of Minnesota Duluth (BS) Yale University (MD) |
Awards | Nobel Prize in Chemistry (2012) |
Scientific career | |
Fields | Crystallography |
Institutions | Stanford University, Duke University |
Academic advisors | Robert Lefkowitz |
Brian Kent Kobilka (born May 30, 1955)
Early life
Kobilka attended St. Mary's Grade School in
Research
Kobilka is best known for his research on the structure and activity of
Kobilka is the 1994 recipient of the American Society for Pharmacology and Experimental Therapeutics John J. Abel Award in Pharmacology.[11] His GPCR structure work was named "runner-up" for the 2007 "Breakthrough of the Year" award from Science.[12] The work was, in part, supported by Kobilka's 2004 Javits Neuroscience Investigator Award[13] from the National Institute of Neurological Disorders and Stroke.[14] He received the 2012 Nobel Prize in Chemistry with Robert Lefkowitz for his work on G protein-coupled receptors.[15][16] In 2017, Kobilka received the Golden Plate Award of the American Academy of Achievement.[17]
As part of Shenzhen’s 13th Five-Year Plan funding research in emerging technologies and opening "Nobel laureate research labs",[18] in 2017 he opened the Kobilka Institute of Innovative Drug Discovery at the CUHK Shenzhen campus in Southern China.[19]
Personal life
Kobilka is from Little Falls in central Minnesota. Both his grandfather Felix J. Kobilka (1893–1991) and his father Franklyn A. Kobilka (1921–2004) were bakers and natives of Little Falls, Minnesota.[20][21][22] Kobilka's grandmother, Isabelle Susan Kobilka (née Medved, 1891–1980), belonged to the Medved and Kiewel families of Prussian immigrants, who from 1888 owned the historical Kiewel brewery in Little Falls. His mother is Betty L. Kobilka (née Faust, b. 1930).
Kobilka met his wife Tong Sun Thian, a Malaysian-Chinese woman,[23] at the University of Minnesota Duluth. They have two children, Jason and Megan Kobilka.[20][24]
References
- ^ "BRIAN K. KOBILKA, MD". Tsinghua University School of Medicine. Archived from the original on 2012-12-16. Retrieved 2013-01-16.
- ^ "Catholic scientist at Stanford shares Nobel Prize for work in chemistry". Catholic News Service. 2012-10-23. Archived from the original on 2013-02-15. Retrieved 2013-01-19.
- S2CID 33620092. Retrieved 2013-01-19.
- ^ "Brian K. Kobilka, M.D." HHMI. Archived from the original on 2014-05-02. Retrieved 2013-01-19.
- ^ "Cell Insights Could Bring Better Drugs". Forbes. Archived from the original on 2011-02-15. Retrieved 2013-01-23.
- S2CID 4407117.
- PMID 17962520.
- S2CID 1559802.
- ^ ScienceWatch.com:"Interview with Brian Kobilka". Archived from the original on 2010-05-08. Retrieved 2008-10-16.
- PMID 19141277.
- ^ "John J. Abel Award". ASPET. Retrieved 2013-01-24.
- ^ "Kobilka's work recognized in magazine award". Stanford University. 2008-01-09. Retrieved 2013-01-24.
- ^ "Javits Neuroscience Investigator Award Recognizes Eight Exemplary Scientists". National Institute of Neurological Disorders and Stroke (NINDS). 2004-11-10. Archived from the original on 2008-10-07. Retrieved 2013-01-24.
- ^ "The Structure of an Important Drug Target Made Crystal Clear". National Institute of Neurological Disorders and Stroke (NINDS). 2007-12-05. Archived from the original on 2008-10-01. Retrieved 2013-01-24.
- ^ Hotz, Robert Lee (October 10, 2012). "U.S. Scientists Win Chemistry Nobel". The Wall Street Journal Online. Retrieved October 10, 2012.
- ^ "Americans Robert Lefkowitz and Brian Kobilka win 2012 Nobel Prize in chemistry". Daily News. AP. 10 October 2012. Retrieved 11 October 2012.
- American Academy of Achievement.
- ^ "Shenzhen Has 7 Nobel Prize Winners' Labs, 3 More Planned". That's Online. Retrieved 2021-03-15.
- ^ "KOBILKA INSTITUTE OF INNOVATIVE DRUG DISCOVERY | CUHK-Shenzhen". lhs.cuhk.edu.cn. Retrieved 2021-03-15.
- ^ a b "Franklyn A. Kobilka, 83". ECM Publishers, Inc. 2004-03-16. Archived from the original on 2012-12-09. Retrieved 2013-01-16.
- ^ Paul Walsh; Alejandra Matos (2012-10-11). "Little Falls bakery helps deliver a sweet reward: Nobel Prize". StarTribune. Retrieved 2013-01-16.
- ^ "Social Security Death Index". Archived from the original on 2012-12-06. Retrieved 2012-10-10.
- ^ 大馬華人女婿獲諾獎‧化學獎得主科比爾卡會煮豉油雞 (in Chinese). 星洲日報. 2012-10-11. Archived from the original on 2012-12-19. Retrieved 2013-01-16.
- PMID 21866135.
Publications
- Bokoch, Michael P.; Zou, Yaozhong; Rasmussen, Søren G.F.; Kobilka, Brian K.; et al. (2010). "Ligand-specific regulation of the extracellular surface of a G-protein-coupled receptor". PMID 20054398.
- Rasmussen, Søren G.F.; DeVree, Brian T.; Zou, Yaozhong; Kobilka, Tong Sun; Kobilka, Brian K.; et al. (2011). "Crystal Structure of the β2 Adrenergic Receptor—Gs Protein Complex". PMID 21772288.
- Haga, Kazuko; Kruse, Andrew C.; Asada, Hidetsugu; Kobilka, Brian K.; et al. (2012). "Structure of the human M2 muscarinic acetylcholine receptor bound to an antagonist". PMID 22278061.
- Manglik, Aashish; Kruse, Andrew C.; Kobilka, Tong Sun; Kobilka, Brian K.; et al. (2012). "Crystal structure of the µ-opioid receptor bound to a morphinan antagonist". PMID 22437502.
External links
- Kobilka laboratory home page
- Brian Kobilka academic profile Archived 2012-10-14 at the Wayback Machine
- ConfometRx home page
- Brian Kobilka on Nobelprize.org