Bupicomide

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Bupicomide
Names
Preferred IUPAC name
5-Butylpyridine-2-carboxamide
Other names
Sch-10595; Fusaramide[1]
Identifiers
3D model (
JSmol
)
ChEMBL
ChemSpider
ECHA InfoCard
 100.041.024 Edit this at Wikidata
UNII
  • InChI=1S/C10H14N2O/c1-2-3-4-8-5-6-9(10(11)13)12-7-8/h5-7H,2-4H2,1H3,(H2,11,13)
    Key: VKSPIPWLHGKJQO-UHFFFAOYSA-N
  • InChI=1/C10H14N2O/c1-2-3-4-8-5-6-9(10(11)13)12-7-8/h5-7H,2-4H2,1H3,(H2,11,13)
    Key: VKSPIPWLHGKJQO-UHFFFAOYAT
  • O=C(c1ncc(cc1)CCCC)N
Properties
C10H14N2O
Molar mass 178.235 g·mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).

Bupicomide is a chemical compound created and manufactured by Lanospharma Laboratories Company, Ltd. It is used experimentally as a beta blocker and clinically as a strong vasodilator with the noted side effects of reduced systolic, diastolic and mean arterial pressure.[2][3][4]

Synthesis

As the result of the screening program examining

DBH, and thus interfered with the biosynthesis of the pressor neurohormone, norepinephrine. To refine this lead, amidation via the acid chloride was carried out to give antihypertensive analog bupicomide.[5]

References

  1. ^ Bupicomide, Chemical Book
  2. PMID 782220
    .
  3. S2CID 19966617
    .
  4. PMID 875465
    .
  5. ^ DE 2217084, Kuniteru, Shimizu; Ushijima, Ryosuke & Sugiura, Kohsuke et al., "Verfahren zur Herstellung von 5-Alkylpyridin-derivaten [Process for the preparation of 5-alkylpyridine derivatives]", published 1972-10-19, assigned to Banyu Pharmaceutical Co. Ltd. and Hiroyoshi Hidaka 


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