CXC chemokine receptors

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CXC chemokine receptors are integral membrane proteins that specifically bind and respond to cytokines of the CXC chemokine family. They represent one subfamily of chemokine receptors, a large family of G protein-linked receptors that are known as seven transmembrane (7-TM) proteins, since they span the cell membrane seven times. There are currently six known CXC chemokine receptors in mammals, named CXCR1 through CXCR6.[1][2]

CXCR1 and CXCR2

neutrophils
in mammals.

CXCR3

NK cells] and is highly induced following cell activation. There are two isoforms, CXCR3-A and CXCR3-B.[5] It has three highly related ligands in mammals, CXCL9, CXCL10 and CXCL11.[6][7]

CXCR4

nerve cells
.

CXCR5

The chemokine receptor

lymphoid tissue. Its principal ligand is CXCL13 (or BLC).[8]

CXCR6

CXCR6 was formerly called three different names (STRL33, BONZO, and TYMSTR) before being assigned CXCR6 based on its chromosomal location (within the chemokine receptor cluster on human chromosome 3p21) and its similarity to other chemokine receptors in its gene sequence. CXCR6 binds the ligand CXCL16. However, CXCR6 is more closely related in structure to CC chemokine receptors than to other CXC chemokine receptors.

History

memory B cells
.

References

External links

  • "Chemokine Receptors". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Archived from the original on 2016-03-03. Retrieved 2008-12-03.