Heck's disease

human papilloma virus types 13 and 32.^[3] It exhibits surface cells with vacuolated cytoplasm around irregular, pyknotic nuclei and occasional cells with mitosis-like changes within otherwise mature and well-differentiated epithelium. A distinguishing histologic feature is elongated rete ridges with mitosoid bodies. It shows 'cobblestone' appearance clinically. It was first identified in the Aboriginal population of North America.^[4]

excisional biopsy for lesions of functional or aesthetic concern.^{[citation needed}