Hexobendine
 | |
| Clinical data | |
|---|---|
| ATC code | |
| Identifiers | |
| |
JSmol) | |
| |
| |
  (what is this?) (verify) | |
Hexobendine is a
vasodilator that acts as an adenosine reuptake inhibitor.[1]
Synthesis
Hexobendine can be synthesized starting with a reaction between 3,4,5-trimethoxybenzoyl chloride (1) and
3-chloropropanol (2) to give the corresponding ester, 3-chloropropyl 3,4,5-trimethoxybenzoate (3). The last step involves the reaction between two molar equivalents of 3 with one molar equivalent of 1,2-dimethylethylenediamine (4) completing the synthesis of hexobendine (5).[2][3]
Synthesis of hexobendine
See also
References
- PMID 1168469.
- ^ "Pharmaceutical Substances: Hexobendine". Thieme.
- ^ AT231432 idem Schlogl Karl, Kraupp Otto, U.S. patent 3,267,103 (1964 & 1966 to Chemie Linz Ag).