Tracazolate

Source: Wikipedia, the free encyclopedia.
Not to be confused with cartazolate.
Tracazolate
Clinical data
Routes of
administration		By mouth
ATC code
  • None
Legal status
Legal status
  • In general: uncontrolled
Identifiers
  • Ethyl 4-(butylamino)-1-ethyl-6-methyl-1H-pyrazolo[3,4-b]pyridine-5-carboxylate
JSmol)
SMILES
  • O=C(OCC)c1c(c2c(nc1C)n(nc2)CC)NCCCC
  • InChI=1S/C16H24N4O2/c1-5-8-9-17-14-12-10-18-20(6-2)15(12)19-11(4)13(14)16(21)22-7-3/h10H,5-9H2,1-4H3,(H,17,19)
  • Key:PCTRYMLLRKWXGF-UHFFFAOYSA-N

Tracazolate (ICI-136,753) is an

derivative, most closely related to pyrazolopyrimidine drugs such as zaleplon, and is one of a structurally diverse group of drugs known as the nonbenzodiazepines which act at the same receptor targets as benzodiazepines but have distinct chemical structures.[1]

Tracazolate has primarily anxiolytic and anticonvulsant effects, with sedative and muscle relaxant effects only appearing at higher doses.[2] It has a unique receptor binding profile involving allosteric modulation of several GABAA receptor subtypes, being selective for GABAA receptors containing α1 and β3 subunits, but exhibiting different effects depending on the third type of subunit making up the receptor complex.[3]

See also

References

  1. S2CID 31584179
    .
  2. PMID 6121711
    .
  3. S2CID 7039885
    .


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