Uridine triphosphate

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Uridine triphosphate
Skeletal formula of UTP
Ball-and-stick model of the UTP molecule as an anion
Names
IUPAC name
Uridine 5′-(tetrahydrogen triphosphate)
Systematic IUPAC name
O1-{[(2R,3S,4R,5R)-5-(2,4-Dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3,4-dihydroxyoxolan-2-yl]methyl} tetrahydrogen triphosphate
Identifiers
ChEMBL
ECHA InfoCard
 100.000.508 Edit this at Wikidata
MeSH Uridine+triphosphate
UNII
Properties
C9H15N2O15P3
Molar mass 484.141
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Uridine-5′-triphosphate (UTP) is a

CTP via CTP synthetase.[1] UTP can be biosynthesized from UDP by Nucleoside Diphosphate Kinase after using the phosphate group from ATP.[2][3] UDP + ATP ⇌ UTP + ADP;[4] both UTP and ATP are energetically equal.[4]

The homologue in DNA is thymidine triphosphate (TTP or dTTP). UTP also has a deoxyribose form (dUTP).

Role in metabolism

UTP also has the role of a source of energy or an activator of substrates in metabolic reactions, like that of

ATP, but more specific. When UTP activates a substrate (like Glucose-1-phosphate), UDP-glucose is formed and inorganic phosphate is released.[5]
UDP-glucuronate is used to conjugate bilirubin to a more water-soluble bilirubin diglucuronide. UTP is also used to activate amino sugars like Glucosamine-1-phosphate to UDP-glucosamine, and N-acetyl-glucosamine-1-phosphate to UDP-N-acetylglucosamine.[6]

Role in receptor mediation

UTP also has roles in mediating responses by extracellular binding to the P2Y receptors of cells. UTP and its derivatives are still being investigated for their applications in human medicine. However, there is evidence from various model systems to suggest it has applications in pathogen defense and injury repair. In mice UTP has been found to interact with P2Y4 receptors to mediate an enhancement in antibody production.[7] In Schwannoma cells, UTP binds to the P2YP receptors in the event of damage.  This leads to the downstream signal cascade that leads to the eventual injury repair.[8]


See also

  • CTP synthase

References

  1. ISBN 978-0-323-29616-8
    .
  2. ISBN 978-0-07-182537-5
    .
  3. ISBN 978-0-323-29616-8
    .
  4. ^
    ISBN 978-0-470-57095-1
    .
  5. ISBN 978-0-07-182537-5
    .
  6. ISBN 978-0-07-182537-5
    .
  7. PMID 24309427
    .
  8. PMID 24905332
    .


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