FMS-like tyrosine kinase 3 ligand
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| Location (UCSC) | Chr 19: 49.47 – 49.49 Mb | Chr 7: 45.13 – 45.14 Mb | |||||||
| PubMed search | [3] | [4] | |||||||
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Fms-related tyrosine kinase 3 ligand (FLT3LG) is a protein which in humans is encoded by the FLT3LG gene.[5][6][7]
Flt3 ligand (FL) is a
FLT3L functions as a
FLT3L is crucial for steady-state plasmacytoid dendritic cell (pDC) and classical dendritic cell (cDC) development.[9][10] A lack of FLT3L results in low levels of dendritic cells.
In parasite clearance
FLT3L and its receptor are involved in the mammalian immune response to malaria. In strains of plasmodium, FLT3L was shown to be released from mast cells and cause the expansion of dendritic cells, leading to the activation of CD8+ T cells. The same paper suggested that FLT3L release was caused by stimulation of mast cells with uric acid, produced from a precursor secreted by the plasmodium parasite. .[11]
In immunotherapy
In situ vaccine (ISV), combining Flt3L, local radiotherapy, and a TLR3 agonist (poly-ICLC), could recruit, antigen-load and activate intratumoral cross-presenting dendritic cells (DCs) in indolent non-Hodgkin’s lymphomas (iNHLs) treatment (clinical trial: NCT01976585).[12] In this study, intratumoral Flt3L was able to (1) induce the accumulation of large numbers of TLR3+ DCs in the tumor and (2) mediate , together with local irradiation, cross-presentation of TAA by DCs in vitro and in vivo.
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000090554 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000110206 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Entrez Gene: FLT3LG fms-related tyrosine kinase 3 ligand".
- S2CID 4309477.
- PMID 7824267.
- PMID 12874263.
- ^ S2CID 5616725.
- PMID 23313573.
- PMID 23685841.
- S2CID 102353110.
Further reading
- Robinson SN, Chavez JM, Pisarev VM, Mosley RL, Rosenthal GJ, Blonder JM, Talmadge JE (March 2003). "Delivery of Flt3 ligand (Flt3L) using a poloxamer-based formulation increases biological activity in mice". Bone Marrow Transplantation. 31 (5): 361–369. PMID 12634727.