Trenbolone acetate

Source: Wikipedia, the free encyclopedia.
Trenbolone acetate
Clinical data
Trade namesFinajet, Finaplix, others
Other namesRU-1697; Trenbolone 17β-acetate; 19-Nor-δ9,11-testosterone 17β-acetate; Estra-4,9,11-trien-17β-ol-3-one 17β-acetate
Routes of
administration		Intramuscular injection
Drug classAndrogen; Anabolic steroid; Androgen ester; Progestogen
Pharmacokinetic data
Elimination half-lifeIntramuscular: 3 days[1]
Identifiers
  • [(8S,13S,14S,17S)-13-Methyl-3-oxo-2,6,7,8,14,15,16,17-octahydro-1H-cyclopenta[a]phenanthren-17-yl] acetate
JSmol)
  • CC(=O)O[C@H]1CC[C@@H]2[C@@]1(C=CC3=C4CCC(=O)C=C4CC[C@@H]23)C
  • InChI=1S/C20H24O3/c1-12(21)23-19-8-7-18-17-5-3-13-11-14(22)4-6-15(13)16(17)9-10-20(18,19)2/h9-11,17-19H,3-8H2,1-2H3/t17-,18+,19+,20+/m1/s1
  • Key:CMRJPMODSSEAPL-FYQPLNBISA-N

Trenbolone acetate, sold under brand names such as Finajet and Finaplix among others, is an

muscle growth in cattle.[2][3][4][5] It is given by injection into muscle.[5][2]

anabolic effects and highly androgenic effects, as well as potent progestogenic effects, and weak glucocorticoid effects.[5][2][7][8][9] Trenbolone acetate is an androgen ester and a short-lasting prodrug of trenbolone
in the body.

Trenbolone acetate was discovered in 1963 and was introduced for veterinary use in the early 1970s.[5][10][11] In addition to its veterinary use, trenbolone acetate is used to improve physique and performance, and is purchased from black market suppliers.[5] The drug is a controlled substance in many countries and so non-veterinary use is generally illicit.[5]

Uses

Veterinary uses

A single cartridge of Finaplix-H containing 10 implants. Each implant contains 10 small yellow pellets. (Image Adapted from Medi-Vet Animal Health, LLC (https://www.medi-vet.com/Finaplix-H-p/16301.html)).

In the livestock industry, trenbolone acetate is more often called Finaplix. It was intentionally developed to promote androgen and gain muscle mass in cattle. Due to its properties, this allows livestock to grow as much muscle as possible before they are transported to a slaughterhouse.

subcutaneous injection into the posterior location of the ear (See Figure) with the use of an implanter gun. Finaplix is consistently implanted until the animal is ready to be slaughtered. There is no withholding period. Due to the common practice of trenbolone acetate use in veterinary medicine, it is quite common to find traces of trenbolone metabolites in cattle worldwide.[10][12]

Image showing the general area of the implantation of Finaplix-H pellets displayed on bovine ear.

Non-medical uses

Bodybuilding

Trenbolone acetate was never approved for use in humans and therefore guidelines for human consumption do not exist.

fluid retention while gaining muscle mass.[10] This allows bodybuilders to appear leaner, and this is why it is more commonly used whilst preparing for competitive events. Trenbolone acetate does not convert into an estrogenic metabolite,[10] and this results in a lack of estrogenic side effects.[5] Trenbolone enanthate is also a very commonly used AAS and lasts much longer than trenbolone acetate with intramuscular injection.[5]

Medical uses

Trenbolone acetate was never approved for use in humans and hence has no medical uses.

wasting syndromes and muscle atrophy, and certain types of anemia.[5][13]

Trenbolone was produced for human use as a human grade product, but only once. The product came in 1.5ml ampoules consisting of 76.2 mg of Trenbolone hexahydrobenzylcarbonate and made by Negma Pharmaceuticals of France. [citation needed]

Side effects

Trenbolone acetate, like any other AAS, has many

androgenic nature of trenbolone acetate facilitates its tendency to produce virilization[7] and this is why it is not recommended for women for physique- or performance-enhancing purposes.[5]
The side effects of trenbolone acetate are similar to other AAS; however, the negative side effects that are specifically facilitated by trenbolone acetate are as follows.

Androgenic

Trenbolone acetate has androgenic activity.

clitoral enlargement, and virilization in general may occur.[5]

Hypogonadism

Trenbolone acetate contributes greatly to muscle mass and feed efficiency; however, administration of the AAS suppresses natural testosterone production; i.e., it has the potential to cause hypogonadism.[5][14][19] This is a common effect of all AAS; the only difference is the variation in how much they suppress in comparison to others.

Cardiovascular

Administration of any AAS can lead to cardiovascular issues.[20] Trenbolone acetate can have a negative and strong impact on cholesterol through suppressing both high-density lipoprotein (HDL) cholesterol and increasing low-density lipoprotein (LDL) cholesterol.[21] When compared to oral AAS, trenbolone acetate has a stronger negative effect on cholesterol levels. This negative effect is much more severe with the use of injectable AAS, particularly trenbolone acetate.[22]

"Tren cough"

The exact mechanisms underlying the cause of the tren cough are not known; however, trenbolone acetate's androgenic effect activates a variety of lipid-like active compounds which are called

EC 1.13.11.33, etc.).[24] The bradykinin peptide is well known to promote a cough reaction associated with ACE inhibitor medications prescribed for hypertension.[25]

Estrogenic and progestogenic

No form of trenbolone, including trenbolone acetate, is

fluid retention is not possible with the administration of this AAS as a result of its not being estrogenic as opposed to testosterone.[5] However, due to trenbolone's potent progestogenic activity, gynecomastia, which is characterized by development and swelling of breast tissue,[26] may still be possible.[citation needed] Stimulation of estrogenic mechanisms are enforced by progestogenic activity[citation needed] as trenbolone acetate and its compounds bind with high affinity to the progesterone receptor.[10][18] It has been assumed that gynecomastia as a result of trenbolone use is due to a buildup of the hormone prolactin;[26] however, a variety of studies conclude that it is the progestogenic activity of trenbolone promoting this and not prolactin.[citation needed] Trenbolone also has a negative impact on blood pressure, but it does not appear to negatively affect most healthy adult men in this way.[citation needed
]

Pharmacology

Pharmacodynamics

The administration of the trenbolone hormone promotes a direct anabolic effect on Androgen Receptor (AR) activity. AR activity facilitated by trenbolone contributes to an increase in IGF-1 and IGF-1R levels, which then enhances skeletal muscle protein accretion. Activation and proliferation of satellite cells then facilitate an increase in skeletal muscle growth.[27]

Trenbolone acetate is a

substrate for aromatase and hence lacks estrogenic activity.[5][2][8] The compound also has weak glucocorticoid activity.[8][9]

Similar to many other AAS, trenbolone acetate has the capability to produce

muscle tissue, ligaments, cartilage, and tendons.[33]

Trenbolone acetate also has the ability to increase red blood cell count. With a larger amount of

anabolic substances that any living organism can consume, and therefore with the administration of trenbolone acetate, every nutrient in the body becomes a lot more valuable.[35] This facilitates an organism's body that is exposed to the AAS to make better use of the nutrients already consumed.[10][35]

Pharmacokinetics

The

elimination half-life of about 3 days.[1]

Chemistry

See also: Androgen ester and List of androgen esters § Trenbolone esters

Trenbolone acetate, or trenbolone 17β-acetate, is a

trenbolone esters include trenbolone enanthate, trenbolone hexahydrobenzylcarbonate, and trenbolone undecanoate.[5][36][37]

Structural properties of major anabolic steroid esters
Anabolic steroid Structure Ester Relative
mol. weight		 Relative
AAS contentb		 Durationc
Position Moiety Type Lengtha
Boldenone undecylenate
C17β Undecylenic acid Straight-chain fatty acid 11 1.58 0.63 Long
Drostanolone propionate
C17β
Propanoic acid
 Straight-chain fatty acid 3 1.18 0.84 Short
Metenolone acetate
C17β
Ethanoic acid
 Straight-chain fatty acid 2 1.14 0.88 Short
Metenolone enanthate
C17β
Heptanoic acid
 Straight-chain fatty acid 7 1.37 0.73 Long
Nandrolone decanoate
C17β
Decanoic acid
 Straight-chain fatty acid 10 1.56 0.64 Long
Nandrolone phenylpropionate
C17β Phenylpropanoic acid Aromatic fatty acid – (~6–7) 1.48 0.67 Long
Trenbolone acetate
C17β
Ethanoic acid
 Straight-chain fatty acid 2 1.16 0.87 Short
Trenbolone enanthated
C17β
Heptanoic acid
 Straight-chain fatty acid 7 1.41 0.71 Long
Footnotes: a = Length of
oil solution
. d = Never marketed. Sources: See individual articles.

Structure–activity relationships

Trenbolone acetate is a modified form of nandrolone.[16] The structure of trenbolone acetate is a 19-nor classification, which represents a structural change of the testosterone hormone. Trenbolone acetate lacks a carbon atom at the 19 position and carries a double bond at carbons 9 and 11. The position of these carbons slows its metabolism, which greatly increases its binding affinity to the AR, and inhibits it from undergoing aromatization into the corresponding estrogenic metabolite. Trenbolone acetate contains trenbolone modified with the addition of a carboxylic acid ester (acetic acid) at the 17β-hydroxyl group.[10] This facilitates the slow release of the AAS from the area of injection.

History

Trenbolone acetate was first synthesized in 1963 and approved by the livestock industry as a growth promoter for beef cattle in the early 1970s.[5][10][11] During this period of its first administration, trenbolone acetate was sold under the names Finajet and Finaject. The original manufacturer of trenbolone acetate discontinued during the late 1980s and administered the synthesis of subcutaneous pellets called Finaplix. These pellets aimed to increase muscle mass and lean tissue of cattle prior to slaughter to increase the profitability of livestock when measured in total pounds of meat sold.[10]

The drug appears to have been an early development project of

trenbolone esters
but trenbolone acetate is the only one known to be produced in veterinary AAS manufacturers.

Trenbolone acetate became popular among bodybuilders and athletes during the early 1980s. During this period, the AAS was transported illegally from Europe in large quantities. Although trenbolone acetate was very popular for a short amount of time, the large amounts of supplies were discontinued in 1987.

sports doping and its negative effects on athletes.[5]

Society and culture

Generic names

Trenbolone acetate is the

generic name of the drug and its USANTooltip United States Adopted Name, USPTooltip United States Pharmacopeia, and BANMTooltip British Approved Name.[3][4][36][37]

Brand names

Trenbolone acetate is or has been sold alone for veterinary use under the brand names Component TH, Component TS, Finaject, Finajet, Finaplix-H, and Finaplix-S.[3][4][5][36][37] It is or has also been sold in combination with estradiol or estradiol benzoate for veterinary use under the brand names Revalor and Synovex.[3][4][5][36][37]

Distribution and regulation

Trenbolone acetate, specifically referred to as Finaplix in the livestock industry, is available to purchase in veterinary drug markets.

drug-trafficking in many countries, including the United States and Australia. However, in the United Kingdom, owning AAS for personal use as a bodybuilding supplement is not illegal, but selling the AAS without a valid medical license or reason is still against the law.[38][39]

Doping in sports

See also:
List of doping in sport cases § Trenbolone esters

Regardless of their legality, AAS are still banned by most sporting leagues in the country, who routinely conduct drug tests to find the users of any AAS. There are known cases of doping in sports with trenbolone acetate by professional athletes.

References

  1. ^
    ISBN 978-1-60547-277-5
    .
  2. ^
    S2CID 205253265
    .
  3. ^
    ISBN 978-94-011-4439-1
    .
  4. ^ a b c d "Trenbolone". Archived from the original on 2020-07-07. Retrieved 2017-11-11.
  5. ^
    ISBN 978-0-9828280-1-4
    .
  6. S2CID 31765638
    .
  7. ^
    PMID 18500378
    .
  8. ^
    ISSN 0804-4643
    .
  9. ^
    PMID 7382482
    .
  10. ^
    S2CID 4706788
    .
  11. ^
    PMID 16818248
    .
  12. PMID 24278538
    .
  13. PMID 11701661
    .
  14. ^
    PMID 1874853
    .
  15. ^ "Trenbolone Acetate - A comprehensive list of side effects". trenacetate.biz. 21 June 2020. Retrieved 2021-02-22.
  16. ^
    PMID 19447393
    .
  17. ^
    S2CID 22776408
    .
  18. ^
    S2CID 8804818
    .
  19. ^
    PMID 2170557
    .
  20. PMID 15084526
    .
  21. PMID 26584015
    .
  22. PMID 26495342
    .
  23. PMID 12007900
    .
  24. S2CID 21643058
    .
  25. S2CID 6040673
    .
  26. ^
    PMID 19880691
    .
  27. PMID 12441365
    .
  28. ISBN 978-0-9828280-1-4
    .
  29. ISBN 978-1-139-49430-4
    .
  30. PMID 782871
    .
  31. PMID 20138077
    .
  32. ^
    PMID 18403176
    .
  33. ^
    PMID 6193805
    .
  34. PMID 20398732
    .
  35. ^
    ISSN 0003-3561
    .
  36. ^
    ISBN 978-1-4757-2085-3
    .
  37. ^
    ISBN 978-3-88763-075-1
    .
  38. ^ "Anabolic Steroids".
  39. ^ "Trenbolone Acetate 100 Norma".

Further reading

External links