Interleukin-7 receptor
Chr. 5 p13 | |||||||
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The
Function
Interleukin-7 receptor has been shown to play a critical role in the development of immune cells called lymphocytes - specifically in a process known as V(D)J recombination[citation needed]. This protein is also found to control the accessibility of a region of the genome that contains the T-cell receptor gamma gene, by STAT5 and histone acetylation [citation needed]. Knockout studies in mice suggest that blocking apoptosis is an essential function of this protein during differentiation and activation of T lymphocytes. Functional defects in this protein may be associated with the pathogenesis of severe combined immunodeficiency (SCID).[5]
Diseases
Several diseases are associated with Interleukin-7 receptor including T-cell acute lymphoblastic leukaemia,[6] multiple sclerosis,[7] rheumatoid arthritis and juvenile idiopathic arthritis.[8]
See also
References
- S2CID 85394260.
- PMID 8266077.
- PMID 9010926.
- ^ "IL2 family". Guide to Pharmacology. IUPHAR/BPS. Retrieved 21 August 2015.
- ^ "Entrez Gene: IL7R interleukin 7 receptor".
- PMID 21892159.
- S2CID 16426835.
- PMID 19744146.
External links
- IL7R+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
This article incorporates text from the United States National Library of Medicine, which is in the public domain.