Interleukin 10 receptor, alpha subunit
IL10RA | |||
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Gene ontology | |||
Molecular function | |||
Cellular component | |||
Biological process | |||
Sources:Amigo / QuickGO |
Ensembl | |||||||||
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UniProt | |||||||||
RefSeq (mRNA) | |||||||||
RefSeq (protein) | |||||||||
Location (UCSC) | Chr 11: 117.99 – 118 Mb | Chr 9: 45.17 – 45.18 Mb | |||||||
PubMed search | [3] | [4] |
View/Edit Human | View/Edit Mouse |
Interleukin-10 receptor subunit alpha is a subunit for the interleukin-10 receptor. IL10RA is its human gene.
IL10RA has also been designated CDw210a (cluster of differentiation w210a).
Function
The protein encoded by this gene is a receptor for
Interactions
Interleukin 10 receptor, alpha subunit has been shown to
interact
with:
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000110324 - Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000032089 - Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Entrez Gene: IL10RA interleukin 10 receptor, alpha".
- PMID 8248239.
- PMID 11485736.
- PMID 7759550.
- PMID 11717514.
- PMID 10231374.
- PMID 12374810.
- PMID 12133952.
Further reading
- Donnelly RP, Dickensheets H, Finbloom DS (1999). "The interleukin-10 signal transduction pathway and regulation of gene expression in mononuclear phagocytes" (PDF). J. Interferon Cytokine Res. 19 (6): 563–73. PMID 10433356.
- Carson WE, Lindemann MJ, Baiocchi R, Linett M, Tan JC, Chou CC, Narula S, Caligiuri MA (1995). "The functional characterization of interleukin-10 receptor expression on human natural killer cells". Blood. 85 (12): 3577–85. PMID 7540068.
- Ho AS, Wei SH, Mui AL, Miyajima A, Moore KW (1995). "Functional regions of the mouse interleukin-10 receptor cytoplasmic domain". Mol. Cell. Biol. 15 (9): 5043–53. PMID 7544437.
- Tan JC, Braun S, Rong H, DiGiacomo R, Dolphin E, Baldwin S, Narula SK, Zavodny PJ, Chou CC (1995). "Characterization of recombinant extracellular domain of human interleukin-10 receptor". J. Biol. Chem. 270 (21): 12906–11. PMID 7759550.
- Taniyama T, Takai S, Miyazaki E, Fukumura R, Sato J, Kobayashi Y, Hirakawa T, Moore KW, Yamada K (1995). "The human interleukin-10 receptor gene maps to chromosome 11q23.3". Hum. Genet. 95 (1): 99–101. S2CID 205672.
- Liu Y, Wei SH, Ho AS, de Waal Malefyt R, Moore KW (1994). "Expression cloning and characterization of a human IL-10 receptor". J. Immunol. 152 (4): 1821–9. PMID 8120391.
- Ho AS, Liu Y, Khan TA, Hsu DH, Bazan JF, Moore KW (1994). "A receptor for interleukin 10 is related to interferon receptors". Proc. Natl. Acad. Sci. U.S.A. 90 (23): 11267–71. PMID 8248239.
- Tan JC, Indelicato SR, Narula SK, Zavodny PJ, Chou CC (1993). "Characterization of interleukin-10 receptors on human and mouse cells". J. Biol. Chem. 268 (28): 21053–9. PMID 8407942.
- Lai CF, Ripperger J, Morella KK, Jurlander J, Hawley TS, Carson WE, Kordula T, Caligiuri MA, Hawley RG, Fey GH, Baumann H (1996). "Receptors for interleukin (IL)-10 and IL-6-type cytokines use similar signaling mechanisms for inducing transcription through IL-6 response elements". J. Biol. Chem. 271 (24): 13968–75. PMID 8662928.
- Zdanov A, Schalk-Hihi C, Wlodawer A (1997). "Crystal structure of human interleukin-10 at 1.6 A resolution and a model of a complex with its soluble receptor". Protein Sci. 5 (10): 1955–62. PMID 8897595.
- Kotenko SV, Krause CD, Izotova LS, Pollack BP, Wu W, Pestka S (1997). "Identification and functional characterization of a second chain of the interleukin-10 receptor complex". EMBO J. 16 (19): 5894–903. PMID 9312047.
- Hoover DM, Schalk-Hihi C, Chou CC, Menon S, Wlodawer A, Zdanov A (1999). "Purification of receptor complexes of interleukin-10 stoichiometry and the importance of deglycosylation in their crystallization". Eur. J. Biochem. 262 (1): 134–41. PMID 10231374.
- Müschen A, Mirmohammadsadegh A, Jarzebska-Deussen B, Abts HF, Ruzicka T, Michel G (1999). "Differential IL-10 receptor gene expression in acute versus chronic atopic eczema. Modulation by immunosuppressive drugs and cytokines in normal cultured keratinocytes". Inflamm. Res. 48 (10): 539–43. S2CID 22779271.
- Corinti S, Albanesi C, la Sala A, Pastore S, Girolomoni G (2001). "Regulatory activity of autocrine IL-10 on dendritic cell functions". J. Immunol. 166 (7): 4312–8. PMID 11254683.
- Josephson K, Logsdon NJ, Walter MR (2001). "Crystal structure of the IL-10/IL-10R1 complex reveals a shared receptor binding site". Immunity. 15 (1): 35–46. PMID 11485736.
- Crepaldi L, Gasperini S, Lapinet JA, Calzetti F, Pinardi C, Liu Y, Zurawski S, de Waal Malefyt R, Moore KW, Cassatella MA (2001). "Up-regulation of IL-10R1 expression is required to render human neutrophils fully responsive to IL-10". J. Immunol. 167 (4): 2312–22. PMID 11490020.
- Zhou JH, Broussard SR, Strle K, Freund GG, Johnson RW, Dantzer R, Kelley KW (2001). "IL-10 inhibits apoptosis of promyeloid cells by activating insulin receptor substrate-2 and phosphatidylinositol 3'-kinase". J. Immunol. 167 (8): 4436–42. PMID 11591769.
- Josephson K, McPherson DT, Walter MR (2002). "Purification, crystallization and preliminary X-ray diffraction of a complex between IL-10 and soluble IL-10R1". Acta Crystallogr. D. 57 (Pt 12): 1908–11. PMID 11717514.
- Wolk K, Kunz S, Asadullah K, Sabat R (2002). "Cutting edge: immune cells as sources and targets of the IL-10 family members?". J. Immunol. 168 (11): 5397–402. PMID 12023331.