CD27
Ensembl | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| UniProt | |||||||||
| RefSeq (mRNA) | |||||||||
| RefSeq (protein) | |||||||||
| Location (UCSC) | Chr 12: 6.44 – 6.45 Mb | Chr 6: 125.21 – 125.21 Mb | |||||||
| PubMed search | [3] | [4] | |||||||
| View/Edit Human | View/Edit Mouse |
CD27 is a member of the
Expression
During mouse embryonic development, specific (medium) expression levels of CD27 (in addition to high
Function
The protein encoded by this gene is a member of the
When CD27 binds CD70, a signaling cascade leads to the differentiation and clonal expansion of T cells.
In murine γδ T cells its expression has been correlated with the secretion of IFNγ.[14]
Clinical significance
As a drug target
Varlilumab is an IgG1 antibody that binds to CD27 and is an experimental cancer treatment.[6] This agonist antibody stimulates CD27 when it binds.[6] The drug is in early clinical trials and appears to stimulate T cells and increase production of cytokines such as interferon-gamma.[6][11]
Interactions
CD27 has been shown to
Mutations
Some mutations can decrease the expression of CD27. Three such mutations, C53Y, C96Y, and R107C, are located in the cysteine-rich domains of CD27.[5]
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000139193 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000030336 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ PMID 29118006.
- ^ a b c d e f Sturgill ER (November 2017). "TNFR agonists: a review of current biologics targeting OX40, 4-1BB, CD27, and GITR". American Journal of Hematology/Oncology. 13 (11): 4–15.
- PMID 8986712.
- ^ PMID 32402290.
- PMID 26834239.
- PMID 29217535.
- ^ S2CID 33534342.
- PMID 28319731.
- ^ "Entrez Gene: CD27 CD27 molecule".
- PMID 19270712.
- PMID 9177220.
- ^ S2CID 22442601.
- ^ PMID 9582383.
Further reading
- Lens SM, de Jong R, Hintzen RQ, Koopman G, van Lier RA, van Oers RH (June 1995). "CD27-CD70 interaction: unravelling its implication in normal and neoplastic B-cell growth". Leukemia & Lymphoma. 18 (1–2): 51–9. PMID 8580829.
- Agematsu K (April 2000). "Memory B cells and CD27". Histology and Histopathology. 15 (2): 573–6. PMID 10809378.
- van Baarle D, Kostense S, van Oers MH, Hamann D, Miedema F (December 2002). "Failing immune control as a result of impaired CD8+ T-cell maturation: CD27 might provide a clue". Trends in Immunology. 23 (12): 586–91. PMID 12464570.
- Dörner T, Lipsky PE (2005). "Correlation of circulating CD27high plasma cells and disease activity in systemic lupus erythematosus". Lupus. 13 (5): 283–9. S2CID 34654758.
External links
- CD27+Antigens at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
- Human CD27 genome location and CD27 gene details page in the UCSC Genome Browser.