Interleukin-4 receptor
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| Location (UCSC) | Chr 16: 27.31 – 27.36 Mb | Chr 7: 125.15 – 125.18 Mb | |||||||
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| Interleukin-4 receptor alpha chain, N-terminal | |||||||||
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The interleukin 4 receptor is a
heterodimer, that is, composed of two subunits. IL4R is the human gene coding for IL-4Rα, the subunit which combines with either common gamma chain (γc, forming the type I IL4 receptor) or with IL-13Rα1 (forming the type II IL4 receptor).[5]
Function
This gene encodes the alpha chain of the interleukin-4 receptor, a
TNFα promote structural changes to vascular endothelial cells, thus playing an important role in tissue inflammation.[7]
The binding of IL-4 or IL-13 to the IL-4 receptor on the surface of
helminth infections.[8]
Interactions
Interleukin-4 receptor has been shown to
Structure
The
Th2-dominated early immune response.[11]
See also
- Macrophage-activating factor
- Macrophage polarization
- Cluster of differentiation
- Fibronectin type III domain
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000077238 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000030748 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- PMID 26187331– via Elsevier ScienceDirect.
- ^ "Entrez Gene: IL4R interleukin 4 receptor".
- PMID 1702807.
- S2CID 43256244.
- PMID 10652211.
- PMID 11714803.
- S2CID 18795930.
Further reading
- Nelms K, Keegan AD, Zamorano J, Ryan JJ, Paul WE (1999). "The IL-4 receptor: signaling mechanisms and biologic functions". Annu. Rev. Immunol. 17 (1): 701–38. PMID 10358772.
- Jiang H, Harris MB, Rothman P (2000). "IL-4/IL-13 signaling beyond JAK/STAT". J. Allergy Clin. Immunol. 105 (6 Pt 1): 1063–70. PMID 10856136.
External links
- CD124+Antigen at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
- PDBe-KB provides an overview of all the structure information available in the PDB for Human Interleukin-4 receptor subunit alpha
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