Interleukin 8 receptor, alpha
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Location (UCSC) | Chr 2: 218.16 – 218.17 Mb | Chr 1: 74.23 – 74.23 Mb | |||||||
PubMed search | [3] | [4] |
View/Edit Human | View/Edit Mouse |
Interleukin 8 receptor, alpha is a
Function
The protein encoded by this gene is a member of the
Clinical significance
Blocking CXCR1 (e.g., with repertaxin[7]) inhibits some human breast cancer stem cells (in vitro and in mice).[8]
In malignant melanoma expression of CXCR1 at the cell surface is present, independent of the cancers stage. It is thought to have a role in the cell growth and angiogenesis required for tumour survival. In this way it has been identified as a potential therapeutic target.[9]
CXCR1 can be cleaved and inactivated by Neutrophil Derived Serine Proteases (NSPs), leading to neutrophil dysfunction and impaired bacterial killing in cystic fibrosis lung disease.[10]
Interactions
Interleukin 8 receptor, alpha has been shown to
See also
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000163464 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000048480 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Entrez Gene: IL8RA interleukin 8 receptor, alpha".
- PMID 21060150.
- PMID 15652230.
- PMID 20051626.
- "Investigators Find Method to Suppress Breast Cancer Stem Cells". Genetic Engineering & Biotechnology News. January 5, 2010. Archived from the original on 2012-08-06.
- PMID 20230195.
- S2CID 9594986.
- S2CID 9744575.
- PMID 8662698.
Further reading
- Ahuja SK, Ozçelik T, Milatovitch A, Francke U, Murphy PM (1992). "Molecular evolution of the human interleukin-8 receptor gene cluster". Nat. Genet. 2 (1): 31–6. S2CID 19732372.
- Lee J, Horuk R, Rice GC, Bennett GL, Camerato T, Wood WI (1992). "Characterization of two high affinity human interleukin-8 receptors". J. Biol. Chem. 267 (23): 16283–7. PMID 1379593.
- Morris SW, Nelson N, Valentine MB, Shapiro DN, Look AT, Kozlosky CJ, Beckmann MP, Cerretti DP (1992). "Assignment of the genes encoding human interleukin-8 receptor types 1 and 2 and an interleukin-8 receptor pseudogene to chromosome 2q35". Genomics. 14 (3): 685–91. PMID 1427896.
- Holmes WE, Lee J, Kuang WJ, Rice GC, Wood WI (1991). "Structure and functional expression of a human interleukin-8 receptor". Science. 253 (5025): 1278–80. PMID 1840701.
- Chuntharapai A, Lee J, Hébert CA, Kim KJ (1994). "Monoclonal antibodies detect different distribution patterns of IL-8 receptor A and IL-8 receptor B on human peripheral blood leukocytes". J. Immunol. 153 (12): 5682–8. S2CID 8872590.
- Chuntharapai A, Kim KJ (1995). "Regulation of the expression of IL-8 receptor A/B by IL-8: possible functions of each receptor". J. Immunol. 155 (5): 2587–94. S2CID 24746695.
- Morohashi H, Miyawaki T, Nomura H, Kuno K, Murakami S, Matsushima K, Mukaida N (1995). "Expression of both types of human interleukin-8 receptors on mature neutrophils, monocytes, and natural killer cells". J. Leukoc. Biol. 57 (1): 180–7. S2CID 7819367.
- Schönbeck U, Brandt E, Petersen F, Flad HD, Loppnow H (1995). "IL-8 specifically binds to endothelial but not to smooth muscle cells". J. Immunol. 154 (5): 2375–83. S2CID 31884586.
- Ahuja SK, Shetty A, Tiffany HL, Murphy PM (1994). "Comparison of the genomic organization and promoter function for human interleukin-8 receptors A and B". J. Biol. Chem. 269 (42): 26381–9. PMID 7929358.
- Sprenger H, Lloyd AR, Meyer RG, Johnston JA, Kelvin DJ (1994). "Genomic structure, characterization, and identification of the promoter of the human IL-8 receptor A gene". J. Immunol. 153 (6): 2524–32. S2CID 12014231.
- Schnitzel W, Monschein U, Besemer J (1994). "Monomer-dimer equilibria of interleukin-8 and neutrophil-activating peptide 2. Evidence for IL-8 binding as a dimer and oligomer to IL-8 receptor B". J. Leukoc. Biol. 55 (6): 763–70. S2CID 5948202.
- Wu D, LaRosa GJ, Simon MI (1993). "G protein-coupled signal transduction pathways for interleukin-8". Science. 261 (5117): 101–3. PMID 8316840.
- Sebok K, Woodside D, al-Aoukaty A, Ho AD, Gluck S, Maghazachi AA (1993). "IL-8 induces the locomotion of human IL-2-activated natural killer cells. Involvement of a guanine nucleotide binding (Go) protein". J. Immunol. 150 (4): 1524–34. S2CID 29083621.
- Cerretti DP, Kozlosky CJ, Vanden Bos T, Nelson N, Gearing DP, Beckmann MP (1993). "Molecular characterization of receptors for human interleukin-8, GRO/melanoma growth-stimulatory activity and neutrophil activating peptide-2". Mol. Immunol. 30 (4): 359–67. PMID 8384312.
- Mollereau C, Muscatelli F, Mattei MG, Vassart G, Parmentier M (1993). "The high-affinity interleukin 8 receptor gene (IL8RA) maps to the 2q33-q36 region of the human genome: cloning of a pseudogene (IL8RBP) for the low-affinity receptor". Genomics. 16 (1): 248–51. PMID 8486366.
- Lloyd A, Modi W, Sprenger H, Cevario S, Oppenheim J, Kelvin D (1993). "Assignment of genes for interleukin-8 receptors (IL8R) A and B to human chromosome band 2q35". Cytogenet. Cell Genet. 63 (4): 238–40. PMID 8500355.
- Damaj BB, McColl SR, Mahana W, Crouch MF, Naccache PH (1996). "Physical association of Gi2alpha with interleukin-8 receptors". J. Biol. Chem. 271 (22): 12783–9. PMID 8662698.
- Ahuja SK, Murphy PM (1996). "The CXC chemokines growth-regulated oncogene (GRO) alpha, GRObeta, GROgamma, neutrophil-activating peptide-2, and epithelial cell-derived neutrophil-activating peptide-78 are potent agonists for the type B, but not the type A, human interleukin-8 receptor". J. Biol. Chem. 271 (34): 20545–50. PMID 8702798.
- Damaj BB, McColl SR, Neote K, Songqing N, Ogborn KT, Hébert CA, Naccache PH (1996). "Identification of G-protein binding sites of the human interleukin-8 receptors by functional mapping of the intracellular loops". FASEB J. 10 (12): 1426–34. S2CID 9744575.
- Jerva LF, Sullivan G, Lolis E (1997). "Functional and receptor binding characterization of recombinant murine macrophage inflammatory protein 2: sequence analysis and mutagenesis identify receptor binding epitopes". Protein Sci. 6 (8): 1643–52. PMID 9260277.
External links
- "Chemokine Receptors: CXCR1". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Archived from the original on 2016-03-03. Retrieved 2008-12-03.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.