Epstein–Barr virus nuclear antigen 1
| Epstein Barr virus nuclear antigen-1, DNA-binding domain | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| Symbol | EBV-NA1 | ||||||||
SCOP2 | 1b3t / SCOPe / SUPFAM | ||||||||
| |||||||||
Epstein–Barr nuclear antigen 1 (EBNA1) is a multifunctional, dimeric viral protein associated with Epstein–Barr virus (EBV).[1] It is the only EBV protein found in all EBV-related malignancies.[2][3] It is important in establishing and maintaining the altered state that cells take when infected with EBV.[2] EBNA1 has a glycine–alanine repeat sequence that separates the protein into amino- and carboxy-terminal domains.[3] This sequence also seems to stabilize the protein, preventing proteasomal breakdown, as well as impairing antigen processing and MHC class I-restricted antigen presentation. This thereby inhibits the CD8-restricted cytotoxic T cell response against virus-infected cells.[4] EBNA1 is expressed from the Qp promoter during all latency programs.[3] It is the only viral protein expressed in latency program I.[1][4]
Function
EBNA1 is integral to many EBV functions including
Though EBNA1 is a well-characterized protein, its role in
Role in epithelial to mesenchymal transition
EBNA1 has been linked to the