Gag-onc fusion protein
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The gag-onc fusion protein
Background
Gag genes are part of a general architecture for
reverse transcription, where the gag region of the genome encodes proteins that constitute the matrix, capsid and nucleocapsid of the mature virus particles. Like in HIV's replication cycle, these proteins are needed for viral budding from the host cell's plasma membrane, where the fully formed virions leave the cell to infect other cells.[3]
gag-v-onc
When a viral gene is introduced into the host cell and is sufficient to induce oncogenesis – the creation of cancerous cells – in the infected cell line, the gene is said to be a "viral transforming gene".[4] When this type of gene is translated to a protein, the protein is called a "transforming protein". Note that since the viral oncogenes originated from a host genome, the transformation event is different from transduction, which describes the process of introducing non-native genes to a host organism via a viral infection.
Rous sarcoma virus
The Gag-v-Onc fusion protein from the
oncogenesis becomes more likely for the infected host cells, since the v-Src gene is translated
into a functionally distinct version of its host counterpart.
murine leukemia virus
In the case of the
murines (mice), the viral life cycle can also be responsible for oncogenesis through a Gag-v-Onc fusion protein called "Mo-MuLV(src)", which is a Gag-v-Src protein capable of inducing oncogenesis in living mice.[7]
See also
- Rous sarcoma virus
- Fusion protein
- Fusion gene
- Fusion transcript
- Chimeric gene
- Bcr-abl fusion protein
- Oncovirus
- Retrovirus
- Retrotransposon
- Retroposon
- Integrase
External links
- gag-onc+Fusion+Proteins at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
- http://www.ijbs.com/v06p0730.htm#headingA7
References
- ^ ISBN 978-0198792765.
- ^ "Oncogene Protein p65(gag-jun) - MeSH - NCBI". www.ncbi.nlm.nih.gov. Retrieved 2017-07-11.
- ^ Principles of Virology, 3rd edition, Vol. 1, Molecular Biology, 2009
- ISBN 978-1-55581-480-9.
- PMID 6273838.
- PMID 6302692.
- S2CID 24552816.