ZEB1
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Zinc finger E-box-binding homeobox 1 is a protein that in humans is encoded by the ZEB1 gene.[5][6][7]
ZEB1 (previously known as TCF8) encodes a
transcription start site.[7][6] ZEB1 and its mammalian paralog ZEB2 belongs to the Zeb family within the ZF (zinc finger) class of homeodomain transcription factors. ZEB1 protein has seven zinc fingers and one homeodomain.[8]
The structure of the homeodomain is shown on the right.
Clinical significance
Mutations of the gene are linked to
epithelial to mesenchymal transition in breast and other carcinomas[9] A recent study suggested its contributing role in lung cancer invasiveness and metastasis development.[10] Overexpression of ZEB1 has been identified as a potential risk factor for recurrence and poor prognosis in several types of cancers.[11]
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000148516 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000024238 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- PMID 1427828.
- ^ PMID 1840704.
- ^ a b "Entrez Gene: ZEB1 zinc finger E-box binding homeobox 1".
- PMID 26464018.
- PMID 15674322.
- PMID 24468793.
- PMID 36076506.
Further reading
- Franklin AJ, Jetton TL, Shelton KD, Magnuson MA (October 1994). "BZP, a novel serum-responsive zinc finger protein that inhibits gene transcription". Molecular and Cellular Biology. 14 (10): 6773–88. PMID 7935395.
- Watanabe Y, Kawakami K, Hirayama Y, Nagano K (December 1993). "Transcription factors positively and negatively regulating the Na,K-ATPase alpha 1 subunit gene". Journal of Biochemistry. 114 (6): 849–55. PMID 8138542.
- Ikeda K, Halle JP, Stelzer G, Meisterernst M, Kawakami K (January 1998). "Involvement of negative cofactor NC2 in active repression by zinc finger-homeodomain transcription factor AREB6". Molecular and Cellular Biology. 18 (1): 10–8. PMID 9418848.
- Turner J, Crossley M (September 1998). "Cloning and characterization of mCtBP2, a co-repressor that associates with basic Krüppel-like factor and other mammalian transcriptional regulators". The EMBO Journal. 17 (17): 5129–40. PMID 9724649.
- Postigo AA, Dean DC (June 1999). "ZEB represses transcription through interaction with the corepressor CtBP". Proceedings of the National Academy of Sciences of the United States of America. 96 (12): 6683–8. PMID 10359772.
- Hlubek F, Löhberg C, Meiler J, Jung A, Kirchner T, Brabletz T (April 2001). "Tip60 is a cell-type-specific transcriptional regulator". Journal of Biochemistry. 129 (4): 635–41. PMID 11275565.
- Locklin RM, Riggs BL, Hicok KC, Horton HF, Byrne MC, Khosla S (December 2001). "Assessment of gene regulation by bone morphogenetic protein 2 in human marrow stromal cells using gene array technology". Journal of Bone and Mineral Research. 16 (12): 2192–204. S2CID 25397480.
- Shaheduzzaman S, Krishnan V, Petrovic A, Bittner M, Meltzer P, Trent J, Venkatesan S, Zeichner S (2002). "Effects of HIV-1 Nef on cellular gene expression profiles". Journal of Biomedical Science. 9 (1): 82–96. PMID 11810028.
- Guaita S, Puig I, Franci C, Garrido M, Dominguez D, Batlle E, Sancho E, Dedhar S, De Herreros AG, Baulida J (October 2002). "Snail induction of epithelial to mesenchymal transition in tumor cells is accompanied by MUC1 repression and ZEB1 expression". The Journal of Biological Chemistry. 277 (42): 39209–16. PMID 12161443.
- Costantino ME, Stearman RP, Smith GE, Darling DS (August 2002). "Cell-specific phosphorylation of Zfhep transcription factor". Biochemical and Biophysical Research Communications. 296 (2): 368–73. PMID 12163027.
- Postigo AA (May 2003). "Opposing functions of ZEB proteins in the regulation of the TGFbeta/BMP signaling pathway". The EMBO Journal. 22 (10): 2443–52. PMID 12743038.
- Postigo AA, Depp JL, Taylor JJ, Kroll KL (May 2003). "Regulation of Smad signaling through a differential recruitment of coactivators and corepressors by ZEB proteins". The EMBO Journal. 22 (10): 2453–62. PMID 12743039.
- Dillner NB, Sanders MM (January 2004). "Transcriptional activation by the zinc-finger homeodomain protein delta EF1 in estrogen signaling cascades". DNA and Cell Biology. 23 (1): 25–34. PMID 14965470.
- Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP (August 2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proceedings of the National Academy of Sciences of the United States of America. 101 (33): 12130–5. PMID 15302935.
- Shimizu S, Krafchak C, Fuse N, Epstein MP, Schteingart MT, Sugar A, Eibschitz-Tsimhoni M, Downs CA, Rozsa F, Trager EH, Reed DM, Boehnke M, Moroi SE, Richards JE (November 2004). "A locus for posterior polymorphous corneal dystrophy (PPCD3) maps to chromosome 10". American Journal of Medical Genetics. Part A. 130A (4): 372–7. PMID 15384081.
External links
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