Retroviral matrix protein
Retroviral matrix proteins are components of
retroviruses. These proteins line the inner surface of viral envelopes and are associated with viral membranes.[1]
Matrix
nucleocapsid (NC) proteins, and some smaller peptides
. Gag-derived proteins govern the entire assembly and release of the virus particles, with matrix proteins playing key roles in Gag stability, capsid assembly, transport and budding.
Families of retroviral matrix proteins
| Gag_MA | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| OPM superfamily | 42 | ||||||||
| OPM protein | 1mn8 | ||||||||
| |||||||||
Although matrix proteins from different viruses appear to perform similar functions and can have similar structural folds, their
structure .[3]
One family of these proteins represents matrix proteins from
eukaryotic endogenous retroviruses, which arise when one or more copies of the retroviral genome becomes integrated into the host genome.[6]
| Retro_M | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| OPM superfamily | 42 | ||||||||
| OPM protein | 1a6s | ||||||||
| |||||||||
Another family represents the M domain of the Gag polyprotein found in avian retroviruses. It includes Gag polyproteins from several avian endogenous retroviruses.[7]
| Gag_p10 | |||||||||
|---|---|---|---|---|---|---|---|---|---|
 solution structure of the m-pmv wild type matrix protein (p10) | |||||||||
| Identifiers | |||||||||
| Symbol | Gag_p10 | ||||||||
| Pfam | PF02337 | ||||||||
| Pfam clan | CL0074 | ||||||||
| InterPro | IPR003322 | ||||||||
| OPM superfamily | 44 | ||||||||
| OPM protein | 2lpy | ||||||||
| |||||||||
Matrix proteins are also components of
beta-retroviruses such as Mason-Pfizer monkey virus (MPMV) and mouse mammary tumor virus (MMTV) .[8][9] This entry also identifies matrix proteins from several eukaryotic endogenous retroviruses.[6]
| Gag_p15 | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| OPM superfamily | 44 | ||||||||
| OPM protein | 1hek | ||||||||
| |||||||||