Hepatitis C virus nonstructural protein 5B
(Redirected from
NS5B
)
Nonstructural protein 5B (NS5B) is a
RNA replication.[2][3][4] Several crystal structures of NS5B polymerase in several crystalline forms have been determined based on the same consensus sequence BK (HCV-BK, genotype 1).[5] The structure can be represented by a right hand shape with fingers, palm, and thumb. The encircled active site, unique to NS5B, is contained within the palm structure of the protein. Recent studies on NS5B protein genotype 1b strain J4's (HC-J4) structure indicate a presence of an active site where possible control of nucleotide binding occurs and initiation of de-novo RNA synthesis. De-novo adds necessary primers for initiation of RNA replication.[6]
Drugs targeting NS5B
Several drugs are either on the market or in various stages of research target NS5B as a means to prevent further
NS5A inhibitors.[7]
- Beclabuvir, currently in clinical trials.
- ).
- Deleobuvir, development terminated.
- Filibuvir, development terminated.
- Radalbuvir, currently in clinical trials.
- Setrobuvir, development terminated.
- Harvoni (combination with ledipasvir)): nucleotide analog, approved by the FDA in December 2013.