Solvent
A solvent (from the
Major uses of solvents are in paints, paint removers, inks, and dry cleaning.
Solutions and solvation
When one substance is
In addition to mixing, the substances in a solution interact with each other at the molecular level. When something is dissolved, molecules of the solvent arrange around
When one substance dissolves into another, a solution is formed. A solution is a homogeneous mixture consisting of a solute dissolved into a solvent. The solute is the substance that is being dissolved, while the solvent is the dissolving medium. Solutions can be formed with many different types and forms of solutes and solvents.
Solvent classifications
Solvents can be broadly classified into two categories: polar and non-polar. A special case is elemental mercury, whose solutions are known as amalgams; also, other metal solutions exist which are liquid at room temperature.
Generally, the
The dielectric constant measures the solvent's tendency to partly cancel the field strength of the electric field of a
Other polarity scales
Dielectric constants are not the only measure of polarity. Because solvents are used by chemists to carry out chemical reactions or observe chemical and biological phenomena, more specific measures of polarity are required. Most of these measures are sensitive to chemical structure.
The Grunwald–Winstein mY scale measures polarity in terms of solvent influence on buildup of positive charge of a solute during a chemical reaction.
Kosower's Z scale measures polarity in terms of the influence of the solvent on UV-absorption maxima of a salt, usually pyridinium iodide or the pyridinium zwitterion.[7]
Donor number and donor acceptor scale measures polarity in terms of how a solvent interacts with specific substances, like a strong
The
Reichardt's dye, a
The polarity, dipole moment, polarizability and
Polarity can be separated to different contributions. For example, the Kamlet-Taft parameters are dipolarity/polarizability (π*), hydrogen-bonding acidity (α) and hydrogen-bonding basicity (β). These can be calculated from the wavelength shifts of 3–6 different solvatochromic dyes in the solvent, usually including Reichardt's dye, nitroaniline and diethylnitroaniline. Another option, Hansen solubility parameters, separates the cohesive energy density into dispersion, polar, and hydrogen bonding contributions.
Polar protic and polar aprotic
Solvents with a dielectric constant (more accurately,
Physical properties
Properties table of common solvents
The solvents are grouped into
Solvent | Chemical formula | Boiling point[10] (°C) |
Dielectric constant[11]
|
Density (g/mL) |
Dipole moment )
(D |
---|---|---|---|---|---|
Nonpolar hydrocarbon solvents | |||||
Pentane |
CH3CH2CH2CH2CH3 |
36.1 | 1.84 | 0.626 | 0.00 |
Hexane |
CH3CH2CH2CH2CH2CH3 |
69 | 1.88 | 0.655 | 0.00 |
Benzene | C6H6 |
80.1 | 2.3 | 0.879 | 0.00 |
Heptane |
H3C(CH2)5CH3 |
98.38 | 1.92 | 0.680 | 0.0 |
Toluene |
C6H5-CH3 |
111 | 2.38 | 0.867 | 0.36 |
Nonpolar ether solvents | |||||
1,4-Dioxane | C4H8O2 |
101.1 | 2.3 | 1.033 | 0.45 |
Diethyl ether |
CH3CH2-O-CH2CH3 |
34.6 | 4.3 | 0.713 | 1.15 |
Tetrahydrofuran (THF) | C4H8O |
66 | 7.5 | 0.886 | 1.75 |
Nonpolar
| |||||
Chloroform |
CHCl3 |
61.2 | 4.81 | 1.498 | 1.04 |
Polar aprotic solvents
| |||||
Dichloromethane (DCM) |
CH2Cl2 |
39.6 | 9.1 | 1.3266 | 1.60 |
Ethyl acetate | CH3-C(=O)-O-CH2-CH3 |
77.1 | 6.02 | 0.894 | 1.78 |
Acetone | CH3-C(=O)-CH3 |
56.1 | 21 | 0.786 | 2.88 |
Dimethylformamide (DMF) | H-C(=O)N(CH3)2 |
153 | 38 | 0.944 | 3.82 |
Acetonitrile (MeCN) |
CH3-C≡N |
82 | 37.5 | 0.786 | 3.92 |
Dimethyl sulfoxide (DMSO) | CH3-S(=O)-CH3 |
189 | 46.7 | 1.092 | 3.96 |
Nitromethane |
CH3-NO2 |
100–103 | 35.87 | 1.1371 | 3.56 |
Propylene carbonate |
C4H6O3 |
240 | 64.0 | 1.205 | 4.9 |
Polar
| |||||
Ammonia |
NH3 |
-33.3 | 17 | 0.674
(at -33.3 °C) |
1.42 |
Formic acid | H-C(=O)OH |
100.8 | 58 | 1.21 | 1.41 |
n-Butanol
|
CH3CH2CH2CH2OH |
117.7 | 18 | 0.810 | 1.63 |
Isopropyl alcohol (IPA) | CH3-CH(-OH)-CH3 |
82.6 | 18 | 0.785 | 1.66 |
n-Propanol |
CH3CH2CH2OH |
97 | 20 | 0.803 | 1.68 |
Ethanol |
CH3CH2OH |
78.2 | 24.55 | 0.789 | 1.69 |
Methanol |
CH3OH |
64.7 | 33 | 0.791 | 1.70 |
Acetic acid | CH3-C(=O)OH |
118 | 6.2 | 1.049 | 1.74 |
Water
|
H-O-H |
100 | 80 | 1.000 | 1.85 |
The ACS Green Chemistry Institute maintains a tool for the selection of solvents based on a principal component analysis of solvent properties.[12]
Hansen solubility parameter values
The
Solvent | Chemical formula | δD Dispersion | δP Polar | δH Hydrogen bonding |
---|---|---|---|---|
Non-polar solvents | ||||
n-Hexane
|
CH3CH2CH2CH2CH2CH3 | 14.9 | 0.0 | 0.0 |
Benzene | C6H6 | 18.4 | 0.0 | 2.0 |
Toluene | C6H5-CH3 | 18.0 | 1.4 | 2.0 |
Diethyl ether | CH3CH2-O-CH2CH3 | 14.5 | 2.9 | 4.6 |
Chloroform | CHCl3 | 17.8 | 3.1 | 5.7 |
1,4-Dioxane | /-CH2-CH2-O-CH2-CH2-O-\ | 17.5 | 1.8 | 9.0 |
Polar aprotic solvents | ||||
Ethyl acetate | CH3-C(=O)-O-CH2-CH3 | 15.8 | 5.3 | 7.2 |
Tetrahydrofuran (THF) | /-CH2-CH2-O-CH2-CH2-\ | 16.8 | 5.7 | 8.0 |
Dichloromethane | CH2Cl2 | 17.0 | 7.3 | 7.1 |
Acetone | CH3-C(=O)-CH3 | 15.5 | 10.4 | 7.0 |
Acetonitrile (MeCN) | CH3-C≡N | 15.3 | 18.0 | 6.1 |
Dimethylformamide (DMF) | H-C(=O)N(CH3)2 | 17.4 | 13.7 | 11.3 |
Dimethyl sulfoxide (DMSO) | CH3-S(=O)-CH3 | 18.4 | 16.4 | 10.2 |
Polar protic solvents | ||||
Acetic acid | CH3-C(=O)OH | 14.5 | 8.0 | 13.5 |
n-Butanol
|
CH3CH2CH2CH2OH | 16.0 | 5.7 | 15.8 |
Isopropanol
|
CH3-CH(-OH)-CH3 | 15.8 | 6.1 | 16.4 |
n-Propanol | CH3CH2CH2OH | 16.0 | 6.8 | 17.4 |
Ethanol | CH3CH2OH | 15.8 | 8.8 | 19.4 |
Methanol | CH3OH | 14.7 | 12.3 | 22.3 |
Formic acid | H-C(=O)OH | 14.6 | 10.0 | 14.0 |
Water
|
H-O-H | 15.5 | 16.0 | 42.3 |
If, for environmental or other reasons, a solvent or solvent blend is required to replace another of equivalent solvency, the substitution can be made on the basis of the Hansen solubility parameters of each. The values for mixtures are taken as the
Boiling point
Solvent | Boiling point (°C)[10] |
---|---|
ethylene dichloride | 83.48 |
pyridine | 115.25 |
methyl isobutyl ketone | 116.5 |
methylene chloride | 39.75 |
isooctane | 99.24 |
carbon disulfide | 46.3 |
carbon tetrachloride | 76.75 |
o-xylene | 144.42 |
The boiling point is an important property because it determines the speed of evaporation. Small amounts of low-boiling-point solvents like diethyl ether, dichloromethane, or acetone will evaporate in seconds at room temperature, while high-boiling-point solvents like water or dimethyl sulfoxide need higher temperatures, an air flow, or the application of vacuum for fast evaporation.
- Low boilers: boiling point below 100 °C (boiling point of water)
- Medium boilers: between 100 °C and 150 °C
- High boilers: above 150 °C
Density
Most organic solvents have a lower density than water, which means they are lighter than and will form a layer on top of water. Important exceptions are most of the halogenated solvents like dichloromethane or chloroform will sink to the bottom of a container, leaving water as the top layer. This is crucial to remember when partitioning compounds between solvents and water in a separatory funnel during chemical syntheses.
Often,
Solvent | Specific gravity[15]
|
---|---|
Pentane | 0.626 |
Petroleum ether | 0.656 |
Hexane | 0.659 |
Heptane | 0.684 |
Diethyl amine | 0.707 |
Diethyl ether | 0.713 |
Triethyl amine | 0.728 |
Tert-butyl methyl ether | 0.741 |
Cyclohexane | 0.779 |
Tert-butyl alcohol | 0.781 |
Isopropanol | 0.785 |
Acetonitrile | 0.786 |
Ethanol | 0.789 |
Acetone | 0.790 |
Methanol | 0.791 |
Methyl isobutyl ketone | 0.798 |
Isobutyl alcohol | 0.802 |
1-Propanol | 0.803 |
Methyl ethyl ketone | 0.805 |
2-Butanol | 0.808 |
Isoamyl alcohol | 0.809 |
1-Butanol | 0.810 |
Diethyl ketone | 0.814 |
1-Octanol | 0.826 |
p-Xylene | 0.861 |
m-Xylene | 0.864 |
Toluene | 0.867 |
Dimethoxyethane | 0.868 |
Benzene | 0.879 |
Butyl acetate | 0.882 |
1-Chlorobutane | 0.886 |
Tetrahydrofuran | 0.889 |
Ethyl acetate | 0.895 |
o-Xylene | 0.897 |
Hexamethylphosphorus triamide | 0.898 |
2-Ethoxyethyl ether | 0.909 |
N,N-Dimethylacetamide | 0.937 |
Diethylene glycol dimethyl ether | 0.943 |
N,N-Dimethylformamide | 0.944 |
2-Methoxyethanol | 0.965 |
Pyridine | 0.982 |
Propanoic acid | 0.993 |
Water | 1.000 |
2-Methoxyethyl acetate | 1.009 |
Benzonitrile | 1.01 |
1-Methyl-2-pyrrolidinone | 1.028 |
Hexamethylphosphoramide | 1.03 |
1,4-Dioxane | 1.033 |
Acetic acid | 1.049 |
Acetic anhydride | 1.08 |
Dimethyl sulfoxide | 1.092 |
Chlorobenzene | 1.1066 |
Deuterium oxide | 1.107 |
Ethylene glycol | 1.115 |
Diethylene glycol | 1.118 |
Propylene carbonate | 1.21 |
Formic acid | 1.22 |
1,2-Dichloroethane | 1.245 |
Glycerin | 1.261 |
Carbon disulfide | 1.263 |
1,2-Dichlorobenzene | 1.306 |
Methylene chloride | 1.325 |
Nitromethane | 1.382 |
2,2,2-Trifluoroethanol | 1.393 |
Chloroform | 1.498 |
1,1,2-Trichlorotrifluoroethane | 1.575 |
Carbon tetrachloride | 1.594 |
Tetrachloroethylene | 1.623 |
Multicomponent solvents
This section needs additional citations for verification. (January 2022) |
Multicomponent solvents appeared after World War II in the
Solvents
Name | Composition |
---|---|
Solvent 645 | toluene 50%, butyl acetate 18%, ethyl acetate 12%, butanol 10%, ethanol 10%. |
Solvent 646 | |
Solvent 647 | butyl- or amyl acetate 29.8%, ethyl acetate 21.2%, butanol 7.7%, toluene or pyrobenzene 41.3%[17] |
Solvent 648 | butyl acetate 50%, ethanol 10%, butanol 20%, toluene 20%[18] |
Solvent 649 | ethyl cellosolve 30%, butanol 20%, xylene 50% |
Solvent 650 | ethyl cellosolve 20%, butanol 30%, xylene 50%[19] |
Solvent 651 | white spirit 90%, butanol 10% |
Solvent KR-36 | butyl acetate 20%, butanol 80% |
Solvent R-4 | toluene 62%, acetone 26%, butyl acetate 12%. |
Solvent R-10 | xylene 85%, acetone 15%. |
Solvent R-12 | toluene 60%, butyl acetate 30%, xylene 10%. |
Solvent R-14 | cyclohexanone 50%, toluene 50%. |
Solvent R-24 | solvent 50%, xylene 35%, acetone 15%. |
Solvent R-40 | toluene 50%, ethyl cellosolve 30%, acetone 20%. |
Solvent R-219 | toluene 34%, cyclohexanone 33%, acetone 33%. |
Solvent R-3160 | butanol 60%, ethanol 40%. |
Solvent RCC | xylene 90%, butyl acetate 10%. |
Solvent RML | ethanol 64%, ethylcellosolve 16%, toluene 10%, butanol 10%. |
Solvent PML-315 | toluene 25%, xylene 25%, butyl acetate 18%, ethyl cellosolve 17%, butanol 15%. |
Solvent PC-1 | toluene 60%, butyl acetate 30%, xylene 10%. |
Solvent PC-2 | white spirit 70%, xylene 30%. |
Solvent RFG | ethanol 75%, butanol 25%. |
Solvent RE-1 | xylene 50%, acetone 20%, butanol 15%, ethanol 15%. |
Solvent RE-2 | petroleum spirits 70%, ethanol 20%, acetone 10%. |
Solvent RE-3 | petroleum spirits 50%, ethanol 20%, acetone 20%, ethyl cellosolve 10%. |
Solvent RE-4 | petroleum spirits 50%, acetone 30%, ethanol 20%. |
Solvent FK-1 (?) | absolute alcohol (99.8%) 95%, ethyl acetate 5% |
Thinners
Name | Composition |
---|---|
Thinner RKB-1 | butanol 50%, xylene 50% |
Thinner RKB-2 | butanol 95%, xylene 5% |
Thinner RKB-3 | xylene 90%, butanol 10% |
Thinner M | ethanol 65%, butyl acetate 30%, ethyl acetate 5%. |
Thinner P-7 | cyclohexanone 50%, ethanol 50%. |
Thinner R-197 | xylene 60%, butyl acetate 20%, ethyl cellosolve 20%. |
Thinner of WFD | toluene 50%, butyl acetate (or amyl acetate) 18%, butanol 10%, ethanol 10%, ethyl acetate 9%, acetone 3%. |
Safety
Fire
Most organic solvents are
Both
In addition some solvents, such as methanol, can burn with a very hot flame which can be nearly invisible under some lighting conditions.[20][21] This can delay or prevent the timely recognition of a dangerous fire, until flames spread to other materials.
Explosive peroxide formation
The heteroatom (
Unless a
To avoid explosive peroxide formation, ethers should be stored in an airtight container, away from light, because both light and air can encourage peroxide formation.[22]
A number of tests can be used to detect the presence of a peroxide in an ether; one is to use a combination of
Peroxides may be removed by washing with acidic iron(II) sulfate, filtering through
Health effects
General health hazards associated with solvent exposure include toxicity to the nervous system, reproductive damage, liver and kidney damage, respiratory impairment, cancer, hearing loss,[25][26] and dermatitis.[27]
Acute exposure
Many solvents[
Chronic exposure
Chronic solvent exposures are often caused by the inhalation of solvent vapors, or the ingestion of diluted solvents, repeated over the course of an extended period.
Some solvents can damage internal organs like the liver, the kidneys, the nervous system, or the brain. The cumulative brain effects of long-term or repeated exposure to some solvents is called chronic solvent-induced encephalopathy (CSE).[31]
Chronic exposure to organic solvents in the work environment can produce a range of adverse neuropsychiatric effects. For example, occupational exposure to organic solvents has been associated with higher numbers of painters suffering from alcoholism.[32] Ethanol has a synergistic effect when taken in combination with many solvents; for instance, a combination of toluene/benzene and ethanol causes greater nausea/vomiting than either substance alone.
Some organic solvents are known or suspected to be cataractogenic. A mixture of
Environmental contamination
A major pathway of induced health effects arises from spills or leaks of solvents, especially chlorinated solvents, that reach the underlying soil. Since solvents readily migrate substantial distances, the creation of widespread soil contamination is not uncommon; this is particularly a health risk if aquifers are affected.[34] Vapor intrusion can occur from sites with extensive subsurface solvent contamination.[35]
See also
- ASTDR
- Construction | Refurbishment | Renovation
- Free energy of solvation
- IARC
- Solvents are often refluxed with an appropriate desiccant prior to distillation to remove water. This may be performed prior to a chemical synthesis where water may interfere with the intended reaction
- List of water-miscible solvents
- Lyoluminescence
- Occupational health
- Partition coefficient (log P) is a measure of differential solubility of a compound in two solvents
- Pollution
- Solvation
- Solvent systems exist outside the realm of ordinary organic solvents: Supercritical fluids, ionic liquids and deep eutectic solvents
- Superfund
- Volatile Organic Compound
- Water model
- Water pollution
References
- ^ "What's the Difference Between Acetone and Non-acetone Nail Polish Remover?". 3 November 2009.
- ISBN 978-3527306732.
- ISBN 978-0-13-026607-1.
- ^ Lowery and Richardson, pp. 181–183
- .
- ^ a b Lowery and Richardson, p. 177.
- ^ Kosower, E.M. (1969) "An introduction to Physical Organic Chemistry" Wiley: New York, p. 293
- .
- ^ Lowery and Richardson, p. 183.
- ^ a b Solvent Properties – Boiling Point Archived 14 June 2011 at the Wayback Machine. Xydatasource.com. Retrieved on 26 January 2013.
- ^ Dielectric Constant Archived 4 July 2010 at the Wayback Machine. Macro.lsu.edu. Retrieved on 26 January 2013.
- .
- ^ ISBN 978-0-9551220-2-6.
- ^ ISBN 978-0-8493-7248-3.
- ^ Selected solvent properties – Specific Gravity Archived 14 June 2011 at the Wayback Machine. Xydatasource.com. Retrieved on 26 January 2013.
- ^ "dcpt.ru Solvent 646 Characteristics (ru)".
- ^ "dcpt.ru Solvent 647 Characteristics (ru)".
- ^ "dcpt.ru Solvent 648 Characteristics (ru)". Archived from the original on 17 May 2017. Retrieved 18 January 2018.
- ^ "dcpt.ru Solvent 650 Characteristics (ru)".
- doi:10.4271/841378. Archivedfrom the original on 12 August 2017.
- ISSN 0010-2202.
- ^ "Peroxides and Ethers | Environmental Health, Safety and Risk Management". www.uaf.edu. Retrieved 25 January 2018.
- ^ "Handling of Peroxide Forming Chemicals". Retrieved 24 September 2021.
- PMID 30411016.
- ^ https://www.cdc.gov/niosh/docs/2018-124/pdfs/2018-124.pdf
- ^ https://pubmed.ncbi.nlm.nih.gov/16938795/
- ^ "Solvents". Occupational Safety & Health Administration. U.S. Department of Labor. Archived from the original on 15 March 2016.
- ^ Rood, David (7 November 2007). "National: Recall ordered for toy that turns into drug". www.theage.com.au.
- S2CID 36652482.
- S2CID 23257894.
- PMID 22560998.
- PMID 1606027.
- S2CID 31344706.
- PMID 26388862.
- PMID 22142966.
Bibliography
- Lowery TH, Richardson KS (1987). Mechanism and Theory in Organic Chemistry (3rd ed.). ISBN 978-0-06-364044-3.
External links
- Solvent selection tool ACS Green Chemistry Institute
- "European Solvents Industry Group - ESIG - ESIG European Solvents Industry Group" Solvents in Europe.
- Table and text O-Chem Lecture
- Tables Properties and toxicities of organic solvents
- CDC – Organic Solvents – NIOSH Workplace Safety and Health Topic
- EPA – Solvent Contaminated Wipes