ML-SI3

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ML-SI3
Identifiers
  • N-[(1S,2S)-2-[4-(2-methoxyphenyl)piperazin-1-yl]cyclohexyl]benzenesulfonamide
JSmol)
  • COC1=CC=CC=C1N2CCN(CC2)[C@H]3CCCC[C@@H]3NS(=O)(=O)C4=CC=CC=C4
  • InChI=1S/C23H31N3O3S/c1-29-23-14-8-7-13-22(23)26-17-15-25(16-18-26)21-12-6-5-11-20(21)24-30(27,28)19-9-3-2-4-10-19/h2-4,7-10,13-14,20-21,24H,5-6,11-12,15-18H2,1H3/t20-,21-/m0/s1
  • Key:OVTXOMMQHRIKGL-SFTDATJTSA-N

ML-SI3 is a chemical compound which acts as an "antagonist" (i.e. channel blocker) of the

TRPML3 channels with lower affinity. It is used for research into the role of TRPML1 and its various functions in lysosomes and elsewhere in the body.[1][2][3][4][5][6][7]

See also

References

  1. PMID 27577094
    .
  2. PMID 26950892
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  3. PMID 28486130
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  4. PMID 31822666
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  5. PMID 31112550
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  6. PMID 32138578
    .
  7. doi:10.1016/j.ejmech.2020.112966
    .
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