Icilin

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Icilin
Names
Preferred IUPAC name
3-(2-Hydroxyphenyl)-6-(3-nitrophenyl)-3,4-dihydropyrimidin-2(1H)-one
Other names
1-(2-Hydroxyphenyl)-4-(3-nitrophenyl)-3,6-dihydropyrimidin-2-one
AG-3-5
Identifiers
3D model (
JSmol
)
ChemSpider
ECHA InfoCard
 100.164.593 Edit this at Wikidata
IUPHAR/BPS
UNII
  • InChI=1S/C16H13N3O4/c20-15-7-2-1-6-14(15)18-9-8-13(17-16(18)21)11-4-3-5-12(10-11)19(22)23/h1-8,10,20H,9H2,(H,17,21) ☒N
    Key: RCEFMOGVOYEGJN-UHFFFAOYSA-N ☒N
  • InChI=1/C16H13N3O4/c20-15-7-2-1-6-14(15)18-9-8-13(17-16(18)21)11-4-3-5-12(10-11)19(22)23/h1-8,10,20H,9H2,(H,17,21)
    Key: RCEFMOGVOYEGJN-UHFFFAOYAQ
  • O=C3N(c1c(O)cccc1)C/C=C(/c2cccc([N+]([O-])=O)c2)N3
Properties
C16H13N3O4
Molar mass 311.29 g/mol
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Icilin (AG-3-5) is a

TRP channels, although despite its high potency it is less selective for TRPM8 over other related ion channels than are other compounds such as WS-12
.

References

  1. S2CID 42844929
    .
  2. PMID 15190109
    .
  3. S2CID 23665244
    .

External links
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