Source: Wikipedia, the free encyclopedia.
Chemical compound
ML2-SA1 JSmol)
InChI=1S/C14H13Cl2NO/c15-9-2-1-3-10(16)12(9)13-11-7-4-5-8(6-7)14(11)18-17-13/h1-3,7-8,11,14H,4-6H2
Key:NBXVMFMMTKYFQP-UHFFFAOYSA-N
ML2-SA1 (EVP-22 ) is a chemical compound which acts as an "agonist" (i.e. channel opener) for the
TRPML3 channels. It has been used to demonstrate the role of TRPM2 in
immune system function, both triggering release of the
chemokine CCL2 from
macrophages and stimulating macrophage migration and endolysosomal trafficking.
[1] [2] See also References
TRPA
TRPC
TRPM
TRPML
TRPP
TRPV
Activators
2-APB 5',6'-EET 9-HODE 9-oxoODE 12S-HETE 12S-HpETE 13-HODE 13-oxoODE 20-HETE )
Allicin (garlic )AM404 Anandamide Bisandrographolide (Andrographis paniculata )
Cannabidiol (cannabis )Cannabidivarin (cannabis )Capsaicin (chili pepper )Carvacrol (oregano , thyme , pepperwort , wild bergamot , others)DHEA Diacyl glycerol Dihydrocapsaicin (chili pepper )Estradiol Eugenol (basil , clove )Evodiamine (Euodia ruticarpa Gingerols (ginger )GSK1016790A Heat Hepoxilin A3
Hepoxilin B3
Homocapsaicin (chili pepper )Homodihydrocapsaicin (chili pepper )Incensole (incense )Lysophosphatidic acid Low pH (acidic conditions)
Menthol (mint )N-Arachidonoyl dopamine N-Oleoyldopamine N-Oleoylethanolamide Nonivamide (PAVA) (PAVA spray )Nordihydrocapsaicin (chili pepper )Paclitaxel (Pacific yew )Paracetamol (acetaminophen) Phenylacetylrinvanil Phorbol esters (e.g., 4α-PDD )Piperine (black pepper , long pepper )Polygodial (Dorrigo pepper )Probenecid Protons RhTx Rutamarin (Ruta graveolens Resiniferatoxin (RTX) (Euphorbia resinifera /pooissonii Shogaols (ginger , Sichuan and melegueta peppers )Tetrahydrocannabivarin (cannabis )Thymol (thyme , oregano )Tinyatoxin (Euphorbia resinifera /pooissonii Tramadol Vanillin (vanilla )Zucapsaicin Blockers
