Octopamine
dopamine β-hydroxylase | |
Metabolism | p-hydroxymandelic acid;[1][2] N-acetyltransferases; phenylethanolamine N-methyltransferase |
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Legal status | |
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Pharmacokinetic data | |
Bioavailability | 99.42 % |
Metabolism | p-hydroxymandelic acid;[1][2] N-acetyltransferases; phenylethanolamine N-methyltransferase |
Elimination half-life | 15 minutes in insects. Between 76 and 175 minutes in humans |
Excretion | Up to 93% of ingested octopamine is eliminated via the urinary route within 24 hours[1] |
Identifiers | |
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JSmol) | |
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Octopamine (molecular formula C8H11NO2; also known as OA, and also norsynephrine, para-octopamine and others) is an
In many types of invertebrates octopamine is an important neurotransmitter and hormone. In protostomes—arthropods, molluscs, and several types of worms—it substitutes for norepinephrine and performs functions apparently similar to those of norepinephrine in mammals, functions that have been described as mobilizing the body and nervous system for action. In mammals octopamine is found only in trace amounts, and no biological function has been solidly established for it. It is also found naturally in numerous plants, including bitter orange.[4][5] Octopamine has been sold under trade names such as Epirenor, Norden, and Norfen for use as a sympathomimetic drug, available by prescription.
Functions
Cellular effects
Octopamine exerts its effects by binding to and activating receptors located on the surface of cells. These receptors have mainly been studied in insects, where they can be divided into distinct types:
- OctαR (alpha-adrenergic-like), are structurally and functionally similar to noradrenergic alpha-1 receptors in mammals. There are multiple subtypes of the OctαR receptor. For example, the kissing bug (Rhodnius prolixus) has Octα1-R, Octα2R.[6]
- OctβR (beta-adrenergic-like), are structurally and functionally similar to noradrenergic beta receptors in mammals. There are multiple subtypes of the OctβR receptor. For example, the fruit fly (Drosophila melanogaster) has DmOctβ1R, DmOctβ2R, and DmOctβ3R.[7]
- OAMB. The diversity of this receptor is relatively unknown. The fruit fly (Drosophila melanogaster) has two distinct isoforms which are functionally distinct: OambK3 and OambAS.[8]
- TyrR (mixed octopamine/tyramine receptors), which are structurally and functionally similar to noradrenergic alpha-2 receptors in mammals.[9] Receptors in the TyrR class, however, are generally more strongly activated by tyramine than by octopamine.[9]
Phylogenetic studies claim that in ancient
In vertebrates no octopamine-specific receptors have been identified. Octopamine binds weakly to receptors for
Invertebrates
Octopamine was first discovered by Italian scientist
In non-insect invertebrates
In lobsters, octopamine seems to direct and coordinate neurohormones to some extent in the central nervous system, and it was observed that injecting octopamine into a lobster and crayfish resulted in limb and abdomen extension.[23]
In the nematode, octopamine is found in high concentrations in adults, decreasing egg-laying and pharyngeal pumping behaviors with an antagonistic effect to serotonin.[24]
Octopaminergic nerves in the mollusc may be present in the heart, with high concentrations in the nervous system.[25]
In non-Drosophila insects
In insects, octopamine is released by a select number of neurons, but acts broadly throughout the central brain, on all sense organs, and on several non-neuronal tissues.
In the honey bee, octopamine has a major role in learning and memory. In the firefly, octopamine release leads to light production in the lantern.[31][32]
In larvae of the oriental armyworm, octopamine is immunologically beneficial, increasing survival rates in high-density populations.[33]
The emerald cockroach wasp stings the host for its larvae (a cockroach) in the head ganglion (brain). The venom blocks octopamine receptors[34] and the cockroach fails to show normal escape responses, grooming itself excessively. It becomes docile and the wasp leads it to the wasp's den by pulling its antenna like a leash.[35]
In Drosophila
Octopamine affects almost every process of the fruit fly and is widely present in both the adult and larval fly. A non-exhaustive list of some of the areas in which Octopamine modulates:
- Learning and memory[36][37][38]
- Ovulation and Egg-Laying[15][16][17][18][19][20]
- Locomotion[39][40][41]
- Muscle Physiology[13][42]
- Aggression[43][44][45]
- Alcohol and drug tolerance[46][47][48][49]
- Feeding[50][51]
- Microbiome and gut physiology[52][53]
- Sleep[54][55]
- Modulating effects of exercise[56][57]
- Metabolism[58][59]
Vertebrates
In
One study noted that octopamine might be an important amine that influences the therapeutic effects of inhibitors such as monoamine oxidase inhibitors, especially because a large increase in octopamine levels was observed when animals were treated with this inhibitor. Octopamine was positively identified in the urine samples of mammals such as humans, rats, and rabbits treated with monoamine oxidase inhibitors. Very small amounts of octopamine were also found in certain animal tissues. It was observed that within a rabbit's body, the heart and kidney held the highest concentrations of octopamine. Octopamine was found to be 93% eluted by urine within 24 hours of being produced in the body as a byproduct of Iproniazid in rabbits.[12]
Pharmacology
Octopamine has been sold under trade names such as Epirenor, Norden, and Norfen for use in medicine as a sympathomimetic drug, available by prescription. However, very little information exists concerning its clinical usefulness or safety.[60]
In
The World Anti-Doping Agency lists octopamine as a banned substance for in competition use, as a "specified stimulant"[62] on the 2019 Prohibited List.
Insecticides
The octopamine receptor is a target of insecticides, as its blockage leads to decreased cyclic adenosine monophosphate (cAMP) levels. Essential oils can have such a neuro-insecticidal effect,[63] and this octopamine-receptor mechanism is naturally utilized by plants with active insecticidal phytochemicals.[64]
Biochemical mechanisms
Mammals
Octopamine is one of four primary
Invertebrates
Octopamine binds to its respective G-protein coupled receptors (GPCRs) to initiate a cell signal transduction pathway. At least three groups of octopamine GPCR have been defined. OctαR (OCTOPAMINE1 receptors) are more closely related to α-adrenergic receptors, while OctβR (OCTOPAMINE2 receptors) are more closely related to β-adrenergic receptors. The Octopamine/Tyramine receptors (including Oct-TyrR) can bind both ligands, and display agonist-specific coupling. Oct-TyrR is listed in both OCTOPAMINE and TYRAMINE RECEPTORS gene groups.[67]
Biosynthesis
In insects
Octopamine acts as the insect equivalent of norepinephrine and has been implicated in regulating aggression in invertebrates, with different effects on different species. Studies have shown that reducing the neurotransmitter octopamine and preventing coding of tyramine beta hydroxylase (an enzyme that converts tyramine to octopamine) decreases aggression in Drosophila without influencing other behaviors.[68]
In humans
See also
References
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