GHB receptor

Source: Wikipedia, the free encyclopedia.
SLC52A2
Identifiers
Gene ontology
Molecular function
Cellular component
Biological process
Sources:Amigo / QuickGO
Ensembl

ENSG00000185803
ENSG00000285112

n/a

UniProt

Q9HAB3

Q9D8F3

RefSeq (mRNA)

NM_029643

RefSeq (protein)

NP_083919

Location (UCSC)Chr 8: 144.33 – 144.36 Mbn/a
PubMed search[2][3]
Wikidata
View/Edit HumanView/Edit Mouse

The γ-hydroxybutyrate (GHB) receptor (GHBR), originally identified as GPR172A, is an excitatory

solute carrier family 52 member 2 (SLC52A2), it is also a transporter for riboflavin
.

History

The existence of a specific GHB receptor was predicted by observing the action of GHB and related compounds that primarily act on the GABAB receptor, but also exhibit a range of effects which were found not to be produced by GABAB activity, and so were suspected of being produced by a novel and at the time unidentified receptor target. Following the discovery of the "orphan" G-protein coupled receptor GPR172A, it was subsequently found to be the GHB receptor whose existence had been previously predicted.[4] The rat GHB receptor was first cloned and characterised in 2003,[5] followed by the human receptor in 2007.[6]

Due to its many functions, this gene has a history of multiple discoveries. In 2002, data mining in the human genome found an incorrectly spliced form of this protein with eight transmembrane helices, and due to the presence of a G-protein binding site, it was correctly assumed to be a GPCR (as GCPR41).

porcine endogenous retrovirus.[8] The same protein was later identified as the GHB receptor in 2007.[6] In 2009, it was identified as a riboflavin transporter, and sorted into SLC family 52 due to sequence similarity. The authors of the 2009 study were not aware of the 2007 study showing that it actually does function as a GPCR.[9]

Function

The function of the GHB receptor appears to be quite different from that of the GABAB receptor. It shares no

glutamate.[10][11][12][13][14][15]

Ligands

Agonists

Antagonists

Prodrugs

Unknown/unclear

References

  1. ^ a b c ENSG00000285112 GRCh38: Ensembl release 89: ENSG00000185803, ENSG00000285112 – Ensembl, May 2017
  2. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. S2CID 84200461
    .
  5. S2CID 489179
    .
  6. ^
    S2CID 6069832
    .
  7. S2CID 7116392
    .
  8. PMID 12740431
    .
  9. PMID 20463145
    .
  10. PMID 10571257
    .
  11. PMID 15745703
    .
  12. S2CID 82175813
    .
  13. PMID 18855733
    .
  14. PMID 16368267
    .
  15. PMID 19010351
    .
  16. S2CID 37091049
    .
  17. PMID 22753476
    .
  18. S2CID 54415695
    .
  19. PMID 10869868
    .
  20. ISBN 978-0-87893-534-5
    .
  21. ISBN 978-0-471-73954-8
    .
  22. PMID 23486087
    .
  23. PMID 19053823
    .
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