Amitriptylinoxide

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Amitriptylinoxide
Skeletal formula of amitriptylinoxide
Ball-and-stick model of the amitriptylinoxide molecule
Clinical data
Trade namesAmioxid, Ambivalon, Equilibrin
Routes of
administration		Oral
ATC code
  • none
Legal status
Legal status
  • In general: ℞ (Prescription only)
Identifiers
  • 3-(10,11-dihydro- 5H-dibenzo[a,d]cycloheptene- 5-ylidene)- N,N-dimethyl- 1-propanamine N-oxide
JSmol)
  • [O-][N+](C)(C)CC/C=C2/c1c(cccc1)CCc3c2cccc3
  • InChI=1S/C20H23NO/c1-21(2,22)15-7-12-20-18-10-5-3-8-16(18)13-14-17-9-4-6-11-19(17)20/h3-6,8-12H,7,13-15H2,1-2H3 checkY
  • Key:ZPMKQFOGINQDAM-UHFFFAOYSA-N checkY
  (verify)

Amitriptylinoxide (brand names Amioxid, Ambivalon, Equilibrin), or amitriptyline N-oxide, is a tricyclic antidepressant (TCA) which was introduced in Europe in the 1970s for the treatment of depression.[1]

Amitriptylinoxide is both an

sweating, and dizziness, orthostatic hypotension, and cardiotoxicity.[2][3][4][5][6][7]

In

α1-adrenergic receptor, and the weakest affinity of any of the TCAs analyzed for the muscarinic acetylcholine receptors.[8][9][10]

Amitriptylinoxide has been said to be a prodrug of amitriptyline.[11]

See also

References

  1. ISBN 3-88763-075-0
    .
  2. ^
    S2CID 12666498
    .
  3. ^
    S2CID 956047
    .
  4. ^
    PMID 4945956
    .
  5. ^
    ISBN 978-0-444-53266-4
    .
  6. PMID 261811
    .
  7. PMID 4947298
    .
  8. S2CID 31927039
    .
  9. S2CID 25823571
    .
  10. PMID 7395525
    .
  11. ISBN 978-3-527-64632-6
    .