Metapramine

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Metapramine
Clinical data
Trade namesProdastene, Timaxel
Routes of
administration		Oral
ATC code
  • none
Legal status
Legal status
  • In general: ℞ (Prescription only)
Pharmacokinetic data
Elimination half-life7–8 hours
Identifiers
  • (rac)-10,11-dihydro-N,5-dimethyl-5H-dibenz[b,f]azepin-10-amine
JSmol)
ChiralityRacemic mixture
  • CNC1CC2=C(C=CC=C2)N(C)C3=CC=CC=C31

Metapramine (brand names Prodastene, Timaxel) is a

affective disorders, it also has analgesic properties,[4][5] and may be useful in the treatment of pain
.

Metapramine has

serotonin, histamine, and muscarinic acetylcholine receptors have not been assayed, but uniquely among most TCAs, it has anecdotally been reported to lack anticholinergic effects.[8][10]

References

  1. ^ US 3622565, Fouche JC, Alexandre CG, "Dibenzazepine derivatives and their preparation", issued 23 November 1971, assigned to Rhone Poulenc SA 
  2. ISBN 0-412-54090-8
    .
  3. ISBN 978-3-527-31058-6
    .
  4. S2CID 39569622
    .
  5. PMID 1731171
    .
  6. PMID 3017518
    .
  7. S2CID 8332732
    .
  8. ^
    PMID 1033059
    .
  9. S2CID 7244740
    .
  10. PMID 2634929
    .