Setiptiline
Clinical data | |
---|---|
Trade names | Tecipul |
Other names | Teciptiline; delta(13b,4a),4a-Carba-mianserin; MO-8282; ORG-8282 |
AHFS/Drugs.com | International Drug Names |
Routes of administration | Oral |
ATC code |
|
Legal status | |
Legal status |
|
Identifiers | |
| |
JSmol) | |
| |
| |
(what is this?) (verify) |
Setiptiline (brand name Tecipul), also known as teciptiline, is a tetracyclic antidepressant (TeCA) that acts as a noradrenergic and specific serotonergic antidepressant (NaSSA). It was launched in 1989 for the treatment of depression in Japan by Mochida.[1][2]
Pharmacology
Pharmacodynamics
Site | Ki (nM) | Species | Ref |
---|---|---|---|
SERT | >10,000 (IC50) | Rat | [4] |
NET | 220 (IC50) | Rat | [4] |
DAT | >10,000 (IC50) | Rat | [4] |
5-HT1A | ND | ND | ND |
5-HT2A | ND | ND | ND |
5-HT2C | ND | ND | ND |
α1 | ND | ND | ND |
α2 | 24.3 (IC50) | Rat | [5] |
H1 | ND | ND | ND |
mACh | ND | ND | ND |
Values are Ki (nM), unless otherwise noted. The smaller the value, the more strongly the drug binds to the site. |
Setiptiline acts as a
]Chemistry
Setiptiline has a tetracyclic structure and is a close analogue of mianserin and mirtazapine, with setiptiline being delta(13b,4a),4a-carba-mianserin, and mirtazapine being 6-azamianserin.
See also
References
- ]
- ISBN 3-88763-075-0.
- ^ Roth BL, Driscol J. "PDSP Ki Database". Psychoactive Drug Screening Program (PDSP). University of North Carolina at Chapel Hill and the United States National Institute of Mental Health. Retrieved 14 August 2017.
- ^ PMID 3792961.
- ^ PMID 2881854.
- PMID 3774630.