Pentostatin
Clinical data | |
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Trade names | Nipent |
AHFS/Drugs.com | Monograph |
MedlinePlus | a692004 |
Routes of administration | Intravenous |
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Pharmacokinetic data | |
Bioavailability | n/a |
Protein binding | 4% |
Metabolism | Hepatic, minor |
Elimination half-life | 2.6 to 16 hours, mean 5.7 hours |
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Pentostatin (or deoxycoformycin, trade name Nipent, manufactured by SuperGen) is an anticancer
Mechanism
It is classified as a
It mimics the nucleoside adenosine and thus inhibits the enzyme adenosine deaminase, interfering with the cell's ability to process DNA.[3]
Cancer cells generally divide more often than healthy cells; DNA is highly involved in cell division (mitosis) and drugs which target DNA-related processes are therefore more toxic to cancer cells than healthy cells.
Uses
Pentostatin is used to treat hairy cell leukemia.[4] It is given by intravenous infusion once every two weeks for three to six months.
Additionally, pentostatin has been used to treat steroid-refractory acute and chronic graft-versus-host disease.[5]
Pentostatin is also used in chronic lymphocytic leukemia (CLL) patients who have relapsed.