Raltitrexed
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AHFS/Drugs.com | Micromedex Detailed Consumer Information |
Routes of administration | Intravenous |
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Raltitrexed (Thaltitrexed, Tomudex, TDX, ZD 1694) is an antimetabolite drug used in cancer chemotherapy. It is an inhibitor of thymidylate synthase, and is manufactured by AstraZeneca.[1]
Uses
Used in treatment of colorectal cancer since 1998, it may also be used in the treatment of malignant mesothelioma.[2] Raltitrexed is approved for use in Canada and some European countries, but is not approved by the US FDA.[3][4]
Mechanism of action
Raltitrexed is chemically similar to
By inhibiting Thymidylate synthase (TS), thus formation of precursor pyrimidine nucleotides, raltitrexed prevents the formation of DNA and RNA, which are required for the growth and survival of both normal cells and cancer cells.
Inhibition of
Structure and phase I clinical trial of the precursor drug, CB3717, was described in 1986.[5]