Thiopurine

Source: Wikipedia, the free encyclopedia.
Thioguanine
Mercaptopurine
Azathioprine

The thiopurine drugs are

organ transplant
recipients.

Metabolism is catalyzed by

S-methyltransferase and nudix hydrolase 15 (NUDT15).[1]

Litigation over patents covering diagnostic kits to monitor the dosing of these drugs led to a US Supreme Court case, Mayo Collaborative Services v. Prometheus Laboratories, Inc. that dramatically changed the nature of patent law in the United States.[2][3]

See also

  • 6-Mercaptopurine
    (6-MP)
  • 6-Thioguanine
    (6-TG)
  • Azathioprine (AZA)

References

  1. PMID 18506437
    .
  2. ^ Supreme Court Decision. Mayo Collaborative Services v. Prometheus Laboratories, Inc., No. 10-1150, Slip Op. at 16. Decision
  3. ^ Gene Quinn, Killing Industry: The Supreme Court Blows Mayo v. Prometheus IP Watchdog (March 20, 2012).

External links