Exisulind

Exisulind
Names
	Preferred IUPAC name [(1Z)-5-Fluoro-1-{[4-(methanesulfanyl)phenyl]methylidene}-2-methyl-1H-inden-3-yl]acetic acid
	Other names Sulindac sulfone, Aptosyn, FGN-1, Prevatac
Identifiers
CAS Number	59973-80-7 ;
3D model ( JSmol)	Interactive image;
ChEBI	CHEBI:64212;
ChEMBL	ChEMBL488025;
ChemSpider	4582441;
PubChem CID	5472495;
UNII	K619IIG2R9 ;
CompTox Dashboard (EPA)	DTXSID6040246 ;
	InChI InChI=1S/C20H17FO4S/c1-12-17(9-13-3-6-15(7-4-13)26(2,24)25)16-8-5-14(21)10-19(16)18(12)11-20(22)23/h3-10H,11H2,1-2H3,(H,22,23)/b17-9- Key: MVGSNCBCUWPVDA-MFOYZWKCSA-N; InChI=1/C20H17FO4S/c1-12-17(9-13-3-6-15(7-4-13)26(2,24)25)16-8-5-14(21)10-19(16)18(12)11-20(22)23/h3-10H,11H2,1-2H3,(H,22,23)/b17-9- Key: MVGSNCBCUWPVDA-MFOYZWKCBW;
	SMILES CC1=C(CC(O)=O)C2=C(C=CC(F)=C2)\C1=C/C1=CC=C(C=C1)S(C)(=O)=O;
Properties
Chemical formula	C20H17FO4S
Molar mass	372.41 g/mol
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). Infobox references

Exisulind (tentative trade name Aptosyn) is an

COX-2 inhibition, p53, Bcl-2, or cell cycle arrest. Preclinical evidence suggests that exisulind also inhibits angiogenesis.^[4]

References

PMID 10656435
.

PMID 11249724
.

PMID 9894180
.

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