Propiomazine

Source: Wikipedia, the free encyclopedia.
Propiomazine
Clinical data
Trade namesPropavan, others
Other namesPropionylpromethazine; CB-1678; Wy-1359; NSC-169450
AHFS/Drugs.comMicromedex Detailed Consumer Information
Routes of
administration		Oral, IM, IV
ATC code
Legal status
Legal status
  • BR: Class C1 (Other controlled substances)[1]
  • In general: ℞ (Prescription only)
Pharmacokinetic data
BioavailabilityOral: 33%[2]
Protein binding81%[3]
Elimination half-life9 hours[2]
Identifiers
  • 1-[10-(2-dimethylaminopropyl)-10H-phenothiazin-2-yl]propan-1-one
JSmol)
  • O=C(c2cc1N(c3c(Sc1cc2)cccc3)CC(N(C)C)C)CC
  • InChI=1S/C20H24N2OS/c1-5-18(23)15-10-11-20-17(12-15)22(13-14(2)21(3)4)16-8-6-7-9-19(16)24-20/h6-12,14H,5,13H2,1-4H3 checkY
  • Key:UVOIBTBFPOZKGP-UHFFFAOYSA-N checkY
  (verify)

Propiomazine, sold under the brand name Propavan among others, is an

dopamine receptors well.[citation needed
]

Medical uses

Propiomazine has been used in the treatment of insomnia.

Side effects

Drowsiness is a usual side effect. Rare, serious side effects include convulsions (seizures); difficult or unusually fast breathing; fast or irregular heartbeat or pulse; fever (high); high or low blood pressure; loss of bladder control; muscle stiffness (severe); unusual increase in sweating; unusually pale skin; and unusual tiredness or weakness.[citation needed]

Pharmacology

Pharmacodynamics

Propiomazine is an

H1 receptor.[citation needed
]

The

hyperprolactinemia than with typical antipsychotics or risperidone.[additional citation(s) needed
]

Chemistry

Propiomazine, also known as 10-(2-dimethylaminopropyl)-2-propionylphenothiazine or as propionylpromethazine, is a

maleate salts.[6][4][7]

Society and culture

Brand names

Propiomazine has been sold under the brand names Dorevan, Dorévane, Indorm, Largon, Phenoctyl, Propavan, Propial, and Serentin.[7][6]

Availability

In 2000, propiomazine continued to be marketed only in Sweden.[6]

References

  1. ^ Anvisa (2023-03-31). "RDC Nº 784 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial" [Collegiate Board Resolution No. 784 - Lists of Narcotic, Psychotropic, Precursor, and Other Substances under Special Control] (in Brazilian Portuguese). Diário Oficial da União (published 2023-04-04). Archived from the original on 2023-08-03. Retrieved 2023-08-16.
  2. ^
    PMID 9327191
    .
  3. ^ "Propiomazine".
  4. ^
    OCLC 1243535030
    .
  5. ^ "NCI Thesaurus". ncit.nci.nih.gov. Retrieved 29 February 2020.
  6. ^
    ISBN 978-3-88763-075-1
    .
  7. ^
    OCLC 50441207
    . Propiomazine**, Propionylpromethazine ... 9600-02 (7787-02) R Maleate (1:1) S 1678 C.B., Dorevan, Dorévane, Indorm, Phenoctyl, Propavan, Propial, Serentin, Wy-1359 U Sedative (pre-anesthetic), hypnotic ...