Hydroxydione

Source: Wikipedia, the free encyclopedia.
Hydroxydione
Clinical data
Trade namesViadril, Predion, Presuren
Other names21-Hydroxy-5β-pregnane-3,20-dione
ATC code
  • None
Legal status
Legal status
Identifiers
  • (5R,8R,9S,10S,13S,14S,17S)-17-(2-hydroxyacetyl)-10,13-dimethyl-1,2,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydrocyclopenta[a]phenanthren-3-one
JSmol)
  • C[C@]12CCC(=O)C[C@H]1CC[C@@H]3[C@@H]2CC[C@]4([C@H]3CC[C@@H]4C(=O)CO)C
  • InChI=1S/C21H32O3/c1-20-9-7-14(23)11-13(20)3-4-15-16-5-6-18(19(24)12-22)21(16,2)10-8-17(15)20/h13,15-18,22H,3-12H2,1-2H3/t13-,15+,16+,17+,18-,20+,21+/m1/s1
  • Key:USPYDUPOCUYHQL-VEVMSBRDSA-N

Hydroxydione, as hydroxydione sodium succinate (

general anesthetic, but was discontinued due to incidence of thrombophlebitis in patients.[5] It was introduced in 1957,[4] and was the first neuroactive steroid general anesthetic to be introduced for clinical use, an event which was shortly preceded by the observation in 1954 of the sedative properties of progesterone in mice.[6]

Chemistry

See also: List of neurosteroids

Related compounds include

alfaxolone, dihydrodeoxycorticosterone, ganaxolone, minaxolone, pregnanolone, and renanolone
.

References

  1. ^ Anvisa (2023-03-31). "RDC Nº 784 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial" [Collegiate Board Resolution No. 784 - Lists of Narcotic, Psychotropic, Precursor, and Other Substances under Special Control] (in Brazilian Portuguese). Diário Oficial da União (published 2023-04-04). Archived from the original on 2023-08-03. Retrieved 2023-08-16.
  2. ISBN 978-3-88763-075-1
    .
  3. ISBN 978-81-224-1565-0
    .
  4. ^
    ISBN 978-0-8155-1856-3
    .
  5. ISBN 978-1-4614-8441-7
    .
  6. ISBN 978-1-4832-7299-3
    .


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