Apronal
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| Clinical data | |
|---|---|
| Routes of administration | Oral |
| ATC code | |
| Pharmacokinetic data | |
| Excretion | Renal |
| Identifiers | |
| |
JSmol) | |
| Chirality | Racemic mixture |
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| |
| (verify) | |
Apronal (brand name Sedormid), or apronalide, also known as allylisopropylacetylurea or allylisopropylacetylcarbamide, is a
heterocyclic ring).[2] In accordance, it is similar in action to the barbiturates, although considerably milder in comparison (formerly used as a daytime sedative at doses of 1 to 2 grams every 3 to 4 hours).[2] Upon the finding that it caused patients to develop thrombocytopenic purpura, apronalide was withdrawn from clinical use.[3]
Medicines with allylisopropylacetylurea are no longer used except in Japan.[3] Notably Australian Therapeutic Goods Administration issued a safety alert in May 2023 which prohibits the sale, supply and use of Japanese EVE-branded products in Australia[4] due to its dangerous side effects.
See also
References
- ^ DE 459903, "Verfahren zur Darstellung von Ureiden der Dialkylessigsaeuren", issued 15 May 1928, assigned to Hoffmann-La Roche
- ^ a b Roche Review ... Hoffman-La Roche, and Roche-organon. 1938. p. 164.
- ^ ISBN 978-1-4831-4178-7.
- ^ "EVE Allylisopropylacetylurea tablets". Therapeutic Goods Administration (TGA). Retrieved 31 May 2023.
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