Barry Marshall
Barry Marshall FAA | |
---|---|
Born | Barry James Marshall 30 September 1951[3] Kalgoorlie, Western Australia |
Alma mater | University of Western Australia (MBBS)[3] |
Known for | Helicobacter pylori |
Spouse |
Adrienne Joyce Feldman
(m. 1972) |
Children | 1 son, 3 daughters[3] |
Awards |
|
Scientific career | |
Fields | |
Institutions | |
Website | www |
Barry James Marshall
Early life and education
Marshall was born in
Career and research
In 1979, Marshall was appointed Registrar in Medicine at the
In 1982 Marshall and Warren obtained funding for one year of research. The first 30 out of 100 samples showed no support for their hypothesis. However, it was discovered that the lab technicians had been throwing out the cultures after two days. This was standard practice for throat swabs where other organisms in the mouth rendered cultures unusable after two days. Due to other hospital work, the lab technicians did not have time to immediately throw out the 31st test on the second day, and so it stayed from Thursday through to the following Monday. In that sample, they discovered the presence of H. pylori. They later found out that H. pylori grows more slowly than the conventional two days required by other mucosal bacteria, and that stomach cultures were not contaminated by other organisms.[14]
In 1983 they submitted their findings thus far to the Gastroenterological Society of Australia, but the reviewers turned their paper down, rating it in the bottom 10% of those they received that year.[14]
After failed attempts to infect piglets in 1984, Sam Wang reported that Marshall, after having a baseline
After his work at Fremantle Hospital, Marshall did research at Royal Perth Hospital (1985–86) and at the University of Virginia, USA (1986–present), before returning to Australia while remaining on the faculty of the University of Virginia.[2] He held a Burnet Fellowship at the University of Western Australia (UWA) from 1998 to 2003.[20] Marshall continues research related to H. pylori and runs the H. pylori Research Laboratory at UWA.[21]
In 2007, Marshall was appointed Co-Director of The Marshall Centre for Infectious Diseases Research and Training, founded in his honour. In addition to Helicobacter pylori research, the Centre conducted varied research into infectious disease identification and surveillance, diagnostics and drug design, and transformative discovery. His research group expanded to embrace new technologies, including
Awards and honours
In 2005, the
Marshall also received the
in 1998.He was elected a
Barry Marshall, together with Robin Warren, discovered spiral bacteria in the stomachs of almost all patients with active chronic gastritis, or duodenal or gastric ulcers, and proposed that the bacteria were an important factor in the aetiology of these diseases. In 1985, Marshall showed by self-administration that this bacterium, now called Helicobacter pylori, causes acute gastritis and suggested that chronic colonisation directly leads to peptic ulceration. These results were a major challenge to the prevailing view that gastric disorders had a physiological basis, rather than being infectious diseases. Marshall showed that antibiotic and bismuth salt regimens that killed H. pylori resulted in the cure of duodenal ulcers. The view that gastric disorders are infectious diseases is now firmly established and there is increasing evidence for a role of H. pylori infection in gastric cancers. The work of Marshall has produced one of the most radical and important changes in medical perception in the last 50 years. Barry Marshall was awarded the Albert Lasker Award for Clinical Science in 1995 and the Buchanan Medal in 1998.
Marshall was awarded the
Marshall was appointed a
Marshall was elected Fellow of the Australian Academy of Health and Medical Sciences (FAHMS) in 2015.[31]
Marshall was awarded the honour of Western Australian of the Year in 2006.[32]
Marshall was awarded The Companion in the General Division of the Order of Australia (AC) in 2007.[33]
Marshall was awarded The University of Oxford honorary Doctor of Science degree in 2009.[34]
Marshall is the Ambassador for Life Sciences for Western Australia.
See also
References
- ^ a b c "Certificate of Election EC/1999/24: Barry James Marshall". London: Royal Society. Archived from the original on 30 December 2017.
- ^ a b "U.Va. Top News Daily". Virginia.edu. 4 October 2005. Archived from the original on 4 April 2010. Retrieved 2 March 2010.
- ^
- ^ "The Marshall Centre". The Marshall Centre. Archived from the original on 31 March 2021. Retrieved 3 May 2021.
- ^ "The University of Western Australia". Archived from the original on 13 October 2008.
- PMID 6134060.
- S2CID 10066001.
- ^ Sweet, Melissa (2 August 1997). "Smug as a bug". The Sydney Morning Herald. Archived from the original on 18 July 2014. Retrieved 28 January 2007.
- ^ a b Barry, Marshall (2005). "Autobiography". Nobel Foundation. Archived from the original on 18 February 2007. Retrieved 28 January 2007.
- ^ In 1972 he was also a state yo-yo champion.
- ^ "Sydney Morning Herald Features Barry Marshall Helicobacter pylori". Vianet.net.au. 2 August 1997. Archived from the original on 18 July 2014. Retrieved 2 March 2010.
- ^ "Barry Marshall Interview, H. Pylori and the Making of a Myth". Academy of Achievement. 23 May 1998. Archived from the original on 24 June 2013. Retrieved 28 January 2007.
- ^ Atwood, Kimball C. (November 2004). "Bacteria, Ulcers, and Ostracism?". Skeptical Inquirer. Archived from the original on 17 October 2013. Retrieved 17 July 2007.
- ^ a b Seeing What Others Don't, chapter 4, by Gary Klein
- ^ "The Doctor Who Drank Infectious Broth, Gave Himself an Ulcer, and Solved a Medical Mystery". Discover Magazine. Archived from the original on 24 January 2018. Retrieved 23 January 2018.
- ^ "Helicobacter Connections: Nobel Lecture, December 8, 2005" (PDF). Nobel Prize. Retrieved 20 January 2024.
- Nobelprize.org. Nobel Media AB. Retrieved 1 August 2013.
- S2CID 42243517.
- PMID 16336147.
- ^ "Professor Barry Marshall". University of Western Australia. 28 July 2006. Archived from the original on 17 February 2007. Retrieved 28 January 2007.
- ^ Marshall, Barry (26 August 2002). "Helicobacter pylori Research Laboratory". University of Western Australia. Archived from the original on 28 January 2007. Retrieved 28 January 2007. Marshall's home page and various links can also be found there.
- ^ "Nobel laureate Marshall joins Penn State faculty". Penn State Live. 6 September 2007. Archived from the original on 25 August 2011. Retrieved 6 September 2007.
- ^ "Noisy Guts : Gut Health Research + Recipes + Products". Retrieved 28 March 2023.
- ^ BrainChip Holdings Ltd: June Quarter Update – August 2020 Archived 9 July 2021 at the Wayback Machine
- ^ "The Nobel Prize in Physiology or Medicine 2005". Nobel Foundation. 2005. Archived from the original on 18 February 2007. Retrieved 28 January 2007.
- American Academy of Achievement.
- ^ "Curriculum Vitae". Nobel Foundation. 2005. Archived from the original on 14 February 2007. Retrieved 28 January 2007.
- ^ "Macfarlane Burnet Medal and Lecture". Australian Academy of Science. Retrieved 22 February 2017.
- Government of Australia. 26 January 2007. Archivedfrom the original on 2 October 2018. Retrieved 28 January 2007.
- ^ "Encaenia 2009". University of Oxford. 24 June 2009. Archived from the original on 4 July 2009. Retrieved 9 September 2009.
- ^ "Fellowship of the Australian Academy of Health & Medical Sciences – October 2015" (PDF). Australian Academy of Health & Medical Sciences. Archived from the original (PDF) on 28 November 2016. Retrieved 12 October 2018.
- ^ "Hall of Fame 2006". Western Australian of the Year. Archived from the original on 18 March 2018. Retrieved 19 April 2021.
- ^ "Australian Honours Lists". Department of the Prime Minister and Cabinet. Archived from the original on 2 October 2018. Retrieved 19 April 2021.
- ^ "University of Oxford Annual Review 2008/2009" (PDF). Archived (PDF) from the original on 24 February 2018. Retrieved 4 May 2021.
External links
- Nobel Prize Inspiration Initiative
- Barry Marshall on Nobelprize.org with the Nobel Lecture Helicobacter Connections
- The Helicobacter Foundation Discussion Pages
- The Helicobacter pylori Research Laboratory
- The Helicobacter Foundation
- Marshall's personal web page
- Interview with Barry Marshall – Radio Live, May 2010.
- Interview with Barry Marshall – BBC World Service 6, 7 and 8 November 2010, Interviewer: Owen Bennett-Jones, Programme series: The Interview.
- The Marshall Centre