Macroevolution

Part of a series on
Evolutionary biology
Darwin's finches by John Gould
Index Introduction Main Outline Glossary Evidence History
Processes and outcomes Population genetics Variation Diversity Mutation Natural selection Adaptation Polymorphism Genetic drift Gene flow Speciation Adaptive radiation Co-operation Coevolution Coextinction Divergence Convergence Parallel evolution Extinction
Natural history Origin of life Common descent History of life Timeline of evolution Human evolution Phylogeny Biodiversity Biogeography Classification Evolutionary taxonomy Cladistics Transitional fossil Extinction event
History of evolutionary theory Overview Renaissance Before Darwin Darwin Origin of Species Before synthesis Modern synthesis Molecular evolution Evo-devo Current research History of speciation History of paleontology (timeline)
Fields and applications Applications of evolution Biosocial criminology Ecological genetics Evolutionary aesthetics Evolutionary anthropology Evolutionary computation Evolutionary ecology Evolutionary economics Evolutionary epistemology Evolutionary ethics Evolutionary game theory Evolutionary linguistics Evolutionary medicine Evolutionary neuroscience Evolutionary physiology Evolutionary psychology Experimental evolution Phylogenetics Paleontology Selective breeding Speciation experiments Sociobiology Island biogeography Systematics Universal Darwinism
Social implications Evolution as fact and theory Social effects Creation–evolution controversy Theistic evolution Objections to evolution Level of support
Evolutionary biology portal  Category
v t e

Macroevolution usually means the evolution of large-scale structures and traits that go significantly beyond the intraspecific variation found in microevolution (including speciation).^[1][2][3] In other words, macroevolution is the evolution of taxa above the species level (genera, families, orders, etc.).^[4]

Macroevolution is often thought to require the evolution of completely new structures such as entirely new organs. However, fundamentally novel structures are not necessary for dramatic evolutionary change. For instance, the evolution of mammal diversity in the past 100 million years has not required any major innovation.^[5] All of this diversity can be explained by modification of existing organs, such as the evolution of elephant tusks from canine teeth.

Origin and changing meaning of the term

Further, species selection[1] suggests that selection among species is a major evolutionary factor that is independent from and complementary to selection among organisms. Accordingly, the level of selection has become the conceptual basis of a third definition, which defines macroevolution as evolution through selection among interspecific variation.^[3]

Macroevolutionary processes

Speciation vs macroevolution

Charles Darwin first discovered that speciation can be extrapolated so that species not only evolve into new species, but also into new genera, families and other groups of animals. In other words, macroevolution is reducible to microevolution through selection of traits over long periods of time.^[13] In addition, some scholars have argued that selection at the species level is important as well.^[14] The advent of genome sequencing enabled the discovery of gradual genetic changes both during speciation but also across higher taxa. For instance, the evolution of humans from ancestral primates or other mammals can be traced to numerous but individual mutations.^[15]

Evolution of new organs and tissues

One of the main questions in evolutionary biology is how new structures evolve, such as new organs. As can be seen in vertebrate evolution, most "new" organs are actually not new—they are still modifications of previously existing organs. Examples are wings (modified limbs), feathers (modified reptile scales),^[16] lungs (modified swim bladders, e.g. found in fish),^[17][18] or even the heart (a muscularized segment of a vein).^[19]

The same concept applies to the evolution of "novel" tissues. Even fundamental tissues such as bone can evolve from combining existing proteins (collagen) with calcium phosphate (specifically, hydroxy-apatite). This probably happened when certain cells that make collagen also accumulated calcium phosphate to get a proto-bone cell.^[20]

Molecular macroevolution

Microevolution is facilitated by mutations, the vast majority of which have no or very small effects on gene or protein function. For instance, the activity of an enzyme may be slightly changed or the stability of a protein slightly altered. However, occasionally mutations can dramatically change the structure and functions of protein. This may be called "molecular macroevolution".

Protein function. There are countless cases in which protein function is dramatically altered by mutations. For instance, a mutation in acetaldehyde dehydrogenase (EC:1.2.1.10) can change it to a 4-hydroxy-2-oxopentanoate pyruvate lyase (EC:4.1.3.39), i.e., a mutation that changes an enzyme from one to another EC class.^[21] Another example is the conversion of a yeast galactokinase (Gal1) to a transcription factor (Gal3) which can be achieved by an insertion of only two amino acids.^[22]

While some mutations may not change the molecular function of a protein significantly, their biological function may be dramatically changed. For instance, most brain receptors recognize specific neurotransmitters, but that specificity can easily be changed by mutations. This has been shown by acetylcholine receptors that can be changed to serotonin or glycine receptors which actually have very different functions. Their similar gene structure also indicates that they must have arisen from gene duplications.^[23]

Protein structure. Although protein structures are highly conserved, sometimes one or a few mutations can dramatically change a protein. For instance, an IgG-binding, 4${\displaystyle \beta }$+${\displaystyle \alpha }$ fold can be transformed into an albumin-binding, 3-α fold via a single amino-acid mutation. This example also shows that such a transition can happen with neither function nor native structure being completely lost.^[24] In other words, even when multiple mutations are required to convert one protein or structure into another, the structure and function is at least partially retained in the intermediary sequences. Similarly, domains can be converted into other domains (and thus other functions). For instance, the structures of SH3 folds can evolve into OB folds which in turn can evolve into CLB folds.^[25]

Examples

Stanley's rule

Macroevolution is driven by differences between species in origination and extinction rates. Remarkably, these two factors are generally positively correlated: taxa that have typically high diversification rates also have high extinction rates. This observation has been described first by Steven Stanley, who attributed it to a variety of ecological factors.^[26] Yet, a positive correlation of origination and extinction rates is also a prediction of the Red Queen hypothesis, which postulates that evolutionary progress (increase in fitness) of any given species causes a decrease in fitness of other species, ultimately driving to extinction those species that do not adapt rapidly enough.^[27] High rates of origination must therefore correlate with high rates of extinction.^[3] Stanley's rule, which applies to almost all taxa and geologic ages, is therefore an indication for a dominant role of biotic interactions in macroevolution.

"Macromutations": Single mutations leading to dramatic change

Normal phenotype

Bithorax phenotype

Mutations in the Ultrabithorax gene lead to a duplication of wings in fruit flies.

While the vast majority of mutations are inconsequential, some can have a dramatic effect on morphology or other features of an organism. One of the best studied cases of a single mutation that leads to massive structural change is the Ultrabithorax mutation in fruit flies. The mutation duplicates the wings of a fly to make it look like a dragonfly, a different order of insect.

Evolution of multicellularity

The evolution of multicellular organisms is one of the major breakthroughs in evolution. The first step of converting a unicellular organism into a metazoan (a multicellular organism) is to allow cells to attach to each other. This can be achieved by one or a few mutations. In fact, many bacteria form multicellular assemblies, e.g. cyanobacteria or myxobacteria. Another species of bacteria, Jeongeupia sacculi, form well-ordered sheets of cells, which ultimately develop into a bulbous structure.^[28][29] Similarly, unicellular yeast cells can become multicellular by a single mutation in the ACE2 gene, which causes the cells to form a branched multicellular form.^[30]

Evolution of bat wings

The wings of bats have the same structural elements (bones) as any other five-fingered mammal (see periodicity in limb development). However, the finger bones in bats are dramatically elongated, so the question is how these bones became so long. It has been shown that certain growth factors such as bone morphogenetic proteins (specifically Bmp2) is over expressed so that it stimulates an elongation of certain bones. Genetic changes in the bat genome identified the changes that lead to this phenotype and it has been recapitulated in mice: when specific bat DNA is inserted in the mouse genome, recapitulating these mutations, the bones of mice grow longer.^[31]

Limb loss in lizards and snakes

Snakes evolved from lizards. Phylogenetic analysis shows that snakes are actually nested within the phylogenetic tree of lizards, demonstrating that they have a common ancestor.^[32] This split happened about 180 million years ago and several intermediary fossils are known to document the origin. In fact, limbs have been lost in numerous clades of reptiles, and there are cases of recent limb loss. For instance, the skink genus Lerista has lost limbs in multiple cases, with all possible intermediary steps, that is, there are species which have fully developed limbs, shorter limbs with 5, 4, 3, 2, 1 or no toes at all.^[33]

Human evolution

While human evolution from their primate ancestors did not require massive morphological changes, our brain has sufficiently changed to allow human consciousness and intelligence. While the latter involves relatively minor morphological changes it did result in dramatic changes to brain function.^[34] Thus, macroevolution does not have to be morphological, it can also be functional.

Evolution of viviparity in lizards

Most lizards are egg-laying and thus need an environment that is warm enough to incubate their eggs. However, some species have evolved viviparity, that is, they give birth to live young, as almost all mammals do. In several clades of lizards, egg-laying (oviparous) species have evolved into live-bearing ones, apparently with very little genetic change. For instance, a European common lizard, Zootoca vivipara, is viviparous throughout most of its range, but oviparous in the extreme southwest portion.^[35][36] That is, within a single species, a radical change in reproductive behavior has happened. Similar cases are known from South American lizards of the genus Liolaemus which have egg-laying species at lower altitudes, but closely related viviparous species at higher altitudes, suggesting that the switch from oviparous to viviparous reproduction does not require many genetic changes.^[37]

Behavior: Activity pattern in mice

Most animals are either active at night or during the day. However, some species switched their activity pattern from day to night or vice versa. For instance, the African striped mouse (Rhabdomys pumilio), transitioned from the ancestrally nocturnal behavior of its close relatives to a diurnal one. Genome sequencing and transcriptomics revealed that this transition was achieved by modifying genes in the rod phototransduction pathway, among others.^[38]

Research topics

Subjects studied within macroevolution include:^[39]

• Cambrian Explosion
  .
• Changes in biodiversity through time.
• Evo-devo (the connection between evolution and developmental biology)
• Genome evolution, like horizontal gene transfer, genome fusions in endosymbioses, and adaptive changes in genome size.
• Mass extinctions.
• Estimating diversification rates, including rates of speciation and extinction.
• The debate between punctuated equilibrium and gradualism.
• The role of development in shaping evolution, particularly such topics as heterochrony and phenotypic plasticity.

See also

• Extinction event
• Interspecific competition
• Microevolution
• Molecular evolution
• Punctuated equilibrium
• Red Queen hypothesis
• Speciation
• Unit of selection

References