Evolution of the brain
This article may be too technical for most readers to understand.(January 2022) |
There is much to be discovered about the evolution of the brain and the principles that govern it. While much has been discovered, not everything currently known is well understood. The evolution of the brain has appeared to exhibit diverging adaptations within taxonomic classes such as Mammalia and more vastly diverse adaptations across other taxonomic classes. Brain to body size scales
Early history of brain development
One approach to understanding overall brain evolution is to use a paleoarchaeological timeline to trace the necessity for ever increasing complexity in structures that allow for chemical and electrical signaling. Because brains and other soft tissues do not fossilize as readily as mineralized tissues, scientists often look to other structures as evidence in the fossil record to get an understanding of brain evolution. This, however, leads to a dilemma as the emergence of organisms with more complex nervous systems with protective bone or other protective tissues that can then readily fossilize occur in the fossil record before evidence for chemical and electrical signaling.[4][5] Evidence from 2008 showed that the ability to transmit electrical and chemical signals existed even before more complex multicellular lifeforms.[4]
Fossilization of brain, or other soft tissue, is possible however, and scientists can infer that the first brain structure appeared at least 521 million years ago, with fossil brain tissue present in sites of exceptional preservation.[6]
Another approach to understanding brain evolution is to look at extant organisms that do not possess complex nervous systems, comparing anatomical features that allow for chemical or electrical messaging. For example, choanoflagellates are organisms that possess various membrane channels that are crucial to electrical signaling. The membrane channels of choanoflagellates' are homologous to the ones found in animal cells, and this is supported by the evolutionary connection between early choanoflagellates and the ancestors of animals.[4] Another example of extant organisms with the capacity to transmit electrical signals would be the glass sponge, a multicellular organism, which is capable of propagating electrical impulses without the presence of a nervous system.[7]
Before the evolutionary development of the brain, nerve nets, the simplest form of a nervous system developed. These nerve nets were a sort of precursor for the more evolutionarily advanced brains. They were first observed in Cnidaria and consist of a number of neurons spread apart that allow the organism to respond to physical contact. They are able to rudimentarily detect food and other chemicals but these nerve nets do not allow them to detect the source of the stimulus.
A trend in brain evolution according to a study done with mice, chickens, monkeys and apes concluded that more evolved species tend to preserve the structures responsible for basic behaviors. A long term human study comparing the human brain to the primitive brain found that the modern human brain contains the primitive hindbrain region – what most neuroscientists call the protoreptilian brain. The purpose of this part of the brain is to sustain fundamental homeostatic functions, which are self regulating processes organisms use to help their bodies adapt. The pons and medulla are major structures found there. A new region of the brain developed in mammals about 250 million years after the appearance of the hindbrain. This region is known as the paleomammalian brain, the major parts of which are the hippocampi and amygdalas, often referred to as the limbic system. The limbic system deals with more complex functions including emotional, sexual and fighting behaviors. Of course, animals that are not vertebrates also have brains, and their brains have undergone separate evolutionary histories.[6]
The brainstem and limbic system are largely based on nuclei, which are essentially balled-up clusters of tightly packed neurons and the axon fibers that connect them to each other, as well as to neurons in other locations. The other two major brain areas (the cerebrum and cerebellum) are based on a cortical architecture. At the outer periphery of the cortex, the neurons are arranged into layers (the number of which vary according to species and function) a few millimeters thick. There are axons that travel between the layers, but the majority of axon mass is below the neurons themselves. Since cortical neurons and most of their axon fiber tracts do not have to compete for space, cortical structures can scale more easily than nuclear ones. A key feature of cortex is that because it scales with surface area, more of it can be fit inside a skull by introducing convolutions, in much the same way that a dinner napkin can be stuffed into a glass by wadding it up. The degree of convolution is generally greater in species with more complex behavior, which benefits from the increased surface area.
The cerebellum, or "little brain," is behind the brainstem and below the occipital lobe of the cerebrum in humans. Its purposes include the coordination of fine sensorimotor tasks, and it may be involved in some cognitive functions, such as language and different motor skills that may involve hands and feet. The cerebellum helps keep equilibrium. Damage to the cerebellum would result in all physical roles in life to be affected. Human cerebellar cortex is finely convoluted, much more so than cerebral cortex. Its interior axon fiber tracts are called the arbor vitae, or Tree of Life.
The area of the brain with the greatest amount of recent evolutionary change is called the neocortex. In reptiles and fish, this area is called the pallium, and is smaller and simpler relative to body mass than what is found in mammals. According to research, the cerebrum first developed about 200 million years ago. It is responsible for higher cognitive functions - for example, language, thinking, and related forms of information processing.[9] It is also responsible for processing sensory input (together with the thalamus, a part of the limbic system that acts as an information router). The thalamus receives the different sensations before it is then passed onto the cerebral cortex. Most of its function is subconscious, that is, not available for inspection or intervention by the conscious mind. The neocortex is an elaboration, or outgrowth, of structures in the limbic system, with which it is tightly integrated. The neocortex is the main part controlling many brain functions as it covers half of the whole brain in volume. The development of these recent evolutionary changes in the neocortex were likely developed as a result of new neural network formations and positive selections of certain genetic components.
Role of embryology in the evolution of the brain
In addition to studying the fossil record, evolutionary history can be investigated via embryology. An embryo is an unborn/unhatched animal and evolutionary history can be studied by observing how processes in embryonic development are conserved (or not conserved) across species. Similarities between different species may indicate evolutionary connection. One way anthropologists study evolutionary connection between species is by observing orthologs. An ortholog is defined as two or more homologous genes between species that are evolutionarily related by linear descent. By using embryology the evolution of the brain can be tracked between various species.
Randomizing access and scaling brains up
Some animal phyla have gone through major brain enlargement through evolution (e.g.
Brain re-arrangement
With the use of in vivo Magnetic resonance imaging (
Dental fossil records for early humans and hominins show that immature hominins, including australopithecines and members of Homo, have a quiescent period (Bown et al. 1987). A quiescent period is a period in which there are no dental eruptions of adult teeth; at this time the child becomes more accustomed to social structure, and development of culture. During this time the child is given an extra advantage over other hominoids, devoting several years into developing speech and learning to cooperate within a community.[14] This period is also discussed in relation to encephalization. It was discovered that chimpanzees do not have this neutral dental period, which suggests that a quiescent period occurred in very early hominin evolution. Using the models for neurological reorganization it can be suggested the cause for this period, dubbed middle childhood, is most likely for enhanced foraging abilities in varying seasonal environments.
Genetic factors of recent evolution
Genes involved in the neuro-development and in neuron physiology are extremely conserved between mammalian species (94% of genes expressed in common between humans and chimpanzees, 75% between humans and mice), compared to other organs. Therefore, few genes account for species differences in the human brain development and function.[15]
Genetic factors linked to the development of the human cerebral cortex and leading to more neurons in the humans
Main differences rely on the evolution of non-coding genomic regions, involved in the regulation of gene expression. This leads to differential expression of genes during the development of the human brain compared to other species, including chimpanzees. Some of these regions evolved fast in the human genome (human accelerated regions). The new genes expressed during human neurogenesis are notably associated with the NOTCH, WNT and mTOR pathways, but are also involved ZEB2, PDGFD and its receptor PDGFRβ. The human cerebral cortex is also characterized by a higher gradient of retinoic acid in the prefrontal cortex, leading to higher prefrontal cortex volume. All these differential gene expression lead to higher proliferation of the neural progenitors leading to more neurons in the human cerebral cortex. Some genes are lost in their expression during the development of the human cerebral cortex like GADD45G and FLRT2/FLRT3.[15]
Another source of molecular novelty rely on new genes in the human or
MCPH1 and ASPM
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Bruce Lahn, the senior author at the Howard Hughes Medical Center at the University of Chicago and colleagues have suggested that there are specific genes that control the size of the human brain. These genes continue to play a role in brain evolution, implying that the brain is continuing to evolve. The study began with the researchers assessing 214 genes that are involved in brain development. These genes were obtained from humans, macaques, rats and mice. Lahn and the other researchers noted points in the DNA sequences that caused protein alterations. These DNA changes were then scaled to the evolutionary time that it took for those changes to occur. The data showed the genes in the human brain evolved much faster than those of the other species. Once this genomic evidence was acquired, Lahn and his team decided to find the specific gene or genes that allowed for or even controlled this rapid evolution. Two genes were found to control the size of the human brain as it develops. These genes are Microcephalin (MCPH1) and Abnormal Spindle-like Microcephaly (ASPM). The researchers at the University of Chicago were able to determine that under the pressures of selection, both of these genes showed significant DNA sequence changes. Lahn's earlier studies displayed that Microcephalin experienced rapid evolution along the primate lineage which eventually led to the emergence of Homo sapiens. After the emergence of humans, Microcephalin seems to have shown a slower evolution rate. On the contrary, ASPM showed its most rapid evolution in the later years of human evolution once the divergence between chimpanzees and humans had already occurred.[16]
Each of the gene sequences went through specific changes that led to the evolution of humans from ancestral relatives. In order to determine these alterations, Lahn and his colleagues used DNA sequences from multiple primates then compared and contrasted the sequences with those of humans. Following this step, the researchers statistically analyzed the key differences between the primate and human DNA to come to the conclusion, that the differences were due to natural selection. The changes in DNA sequences of these genes accumulated to bring about a competitive advantage and higher fitness that humans possess in relation to other primates. This comparative advantage is coupled with a larger brain size which ultimately allows the human mind to have a higher cognitive awareness.[17]
ZEB2
ZEB2 is a protein- coding gene in the Homo sapien species. A 2021 study found that a delayed change in the shape of
NOVA1
In 2021, researchers reported that
Genetic factors linked to neuronal maturation: SRGAP2C and the human neoteny
Less is known about
Genetic factors linked to neuronal physiology: LRRC37B and the electrical properties of human neurons
Even less is known about molecular specificities linked to the physiology of the human neurons. Human neurons are more divergent in the genes they express compared to chimpanzees than chimpanzees to gorilla, which suggests an acceleration of non-coding genomic regions associated with genes involved in neuronal physiology, in particular linked to the synapses.
Genome repair
The genomic DNA of postmitotic neurons ordinarily does not replicate. Protection strategies have evolved to ensure the distinctive longevity of the neuronal genome. Human neurons are reliant on DNA repair processes to maintain function during an individual's life-time. DNA repair tends to occur preferentially at evolutionarily conserved sites that are specifically involved with the regulation of expression of genes essential for neuronal identity and function.[29]
Other factors
Many other genetics may also be involved in recent evolution of the brain.
- For instance, scientists showed experimentally, with brain organoids grown from stem cells, how differences between humans and chimpanzees are also substantially caused by non-coding DNA (often discarded as relatively meaningless "junk DNA") – in particular via CRE-regulated expression of the ZNF558 gene for a transcription factor that regulates the SPATA18 gene.[30][31] SPATA18 gene encodes a protein and is able to influence lysosome-like organelles that are found within mitochondria that eradicate oxidized mitochondrial proteins. This helps monitor the quality of the mitochondria as the disregulation of its quality control has been linked to cancer and degenerative diseases.[32] This example may contribute to illustrations of the complexity and scope of relatively recent evolution to Homo sapiens.[33]
- A change in gene TKTL1 could be a key factor of recent brain evolution and difference of modern humans to (other) apes and Neanderthals, related to neocortex-neurogenesis.[34][35]
- Some of the prior study's authors reported a similar ARHGAP11B mutation in 2016.[36][37]
- Epigenetics also play a major role in the brain evolution in and to humans.[38][further explanation needed]
By recently evolved trait
- Language
A genome-wide association study meta-analysis reported genetic factors of, the so far uniquely human, language-related capacities, in particular factors of differences in skill-levels of five tested traits. It e.g. identified association with neuroanatomy of a language-related brain area via neuroimaging correlation. The data contributes to identifying or understanding the biological basis of this recently evolved characteristic capability.[39][40]
Evolution of the human brain
One of the prominent ways of tracking the evolution of the human brain is through direct evidence in the form of fossils. The evolutionary history of the human brain shows primarily a gradually bigger brain relative to body size during the evolutionary path from early primates to hominids and finally to Homo sapiens. Because fossilized brain tissue is rare, a more reliable approach is to observe anatomical characteristics of the skull that offer insight into brain characteristics. One such method is to observe the endocranial cast (also referred to as endocasts). Endocasts occur when, during the fossilization process, the brain deteriorates away, leaving a space that is filled by surrounding sedimentary material over time. These casts, give an imprint of the lining of the brain cavity, which allows a visualization of what was there.[41][42] This approach, however, is limited in regard to what information can be gathered. Information gleaned from endocasts is primarily limited to the size of the brain (cranial capacity or endocranial volume), prominent sulci and gyri, and size of dominant lobes or regions of the brain.[43][44] While endocasts are extremely helpful in revealing superficial brain anatomy, they cannot reveal brain structure, particularly of deeper brain areas. By determining scaling metrics of cranial capacity as it relates to total number of neurons present in primates, it is also possible to estimate the number of neurons through fossil evidence.[45]
Despite the limitations to endocasts, they can and do provide a basis for understanding human brain evolution, which shows primarily a gradually bigger brain. The evolutionary history of the human brain shows primarily a gradually bigger brain relative to body size during the evolutionary path from early primates to hominins and finally to Homo sapiens. This trend that has led to the present day human brain size indicates that there has been a 2-3 factor increase in size over the past 3 million years.[44] This can be visualized with current data on hominin evolution, starting with Australopithecus—a group of hominins from which humans are likely descended.[46] After all of the data, all observations concluded that the main development that occurred during evolution was the increase of brain size.[47]
However, recent research has called into question the hypothesis of a threefold increase in brain size when comparing Homo sapiens with Australopithecus and chimpanzees. For example, in an article published in 2022 compiled a large data set of contemporary humans and found that the smallest human brains are less than twice that of large brained chimpanzees. As the authors write '...the upper limit of chimpanzee brain size is 500g/ml yet numerous modern humans have brain size below 900 g/ml.'[48] Consequently, the authors argue that the notion of an increase in brain size being related to advances in cognition needs to be re-thought in light of global variation in brain size, as the brains of many modern humans with normal cognitive capacities are only 400g/ml larger than chimpanzees. Additionally, much of the increase in brain size - which occurs to a much greater degree in specific modern populations - can be explained by increases in correlated body size related to diet and climatic factors.[48]
Australopiths lived from 3.85 to 2.95 million years ago with the general cranial capacity somewhere near that of the extant chimpanzee—around 300–500 cm3.[49][50] Considering that the volume of the modern human brain is around 1,352 cm3 on average this represents a substantial amount of brain mass evolved.[51] Australopiths are estimated to have a total neuron count of ~30-35 billion.[45]
Progressing along the human ancestral timeline, brain size continues to steadily increase (see Homininae) when moving into the era of Homo. For example, Homo habilis, living 2.4 million to 1.4 million years ago and argued to be the first Homo species based on a host of characteristics, had a cranial capacity of around 600 cm3.[52] Homo habilis is estimated to have had ~40 billion neurons.[45]
A little closer to present day, Homo heidelbergensis lived from around 700,000 to 200,000 years ago and had a cranial capacity of around 1290 cm3[52] and having around 76 billion neurons.[45]
Homo neaderthalensis, living 400,000 to 40,000 years ago, had a cranial capacity comparable to that of modern humans at around 1500–1600 cm3on average, with some specimens of Neanderthal having even greater cranial capacity.[53][54] Neanderthals are estimated to have had around 85 billion neurons.[45] The increase in brain size topped with Neanderthals, possibly due to their larger visual systems.[55]
It is also important to note that the measure of brain mass or volume, seen as cranial capacity, or even relative brain size, which is brain mass that is expressed as a percentage of body mass, are not a measure of intelligence, use, or function of regions of the brain.[45] Total neurons, however, also do not indicate a higher ranking in cognitive abilities. Elephants have a higher number of total neurons (257 billion)[56] compared to humans (100 billion).[57][58] Relative brain size, overall mass, and total number of neurons are only a few metrics that help scientists follow the evolutionary trend of increased brain to body ratio through the hominin phylogeny.
In 2021, scientists suggested that the brains of early Homo from Africa and
Evolution of the neocortex
In addition to just the size of the brain, scientists have observed changes in the folding of the brain, as well as in the thickness of the cortex. The more convoluted the surface of the brain is, the greater the surface area of the cortex which allows for an expansion of cortex. It is the most evolutionarily advanced part of the brain.[62] Greater surface area of the brain is linked to higher intelligence as is the thicker cortex but there is an inverse relationship—the thicker the cortex, the more difficult it is for it to fold. In adult humans, thicker cerebral cortex has been linked to higher intelligence.[62]
The neocortex is the most advanced and most evolutionarily young part of the human brain. It is six layers thick and is only present in mammals. It is especially prominent in humans and is the location of most higher level functioning and cognitive ability.[63] The six-layered neocortex found in mammals is evolutionarily derived from a three-layer cortex present in all modern reptiles.[64] This three-layer cortex is still conserved in some parts of the human brain such as the hippocampus and is believed to have evolved in mammals to the neocortex during the transition between the Triassic and Jurassic periods.[64][63] After looking at history, the mammals had little neocortex compared to the primates as they had more cortex.[65] The three layers of this reptilian cortex correlate strongly to the first, fifth and sixth layers of the mammalian neocortex.[66] Across species of mammals, primates have greater neuronal density compared to rodents of similar brain mass and this may account for increased intelligence.[63]
Theories of human brain evolution
Explanations of the rapid evolution and exceptional size of the human brain can be classified into five groups: instrumental, social, environmental, dietary, and anatomo-physiological. The instrumental hypotheses[67] are based on the logic that evolutionary selection for larger brains is beneficial for species survival, dominance, and spread, because larger brains facilitate food-finding and mating success. The social hypotheses[67] suggest that social behavior stimulates evolutionary expansion of brain size.[68] Similarly, the environmental hypotheses suppose that encephalization is promoted by environmental factors such as stress, variability, and consistency.[69] The dietary theories maintain that food quality and certain nutritional components directly contributed to the brain growth in the Homo genus.[70] The anatomo-physiologic concepts, such as cranio-cerebral vascular hypertension due to head-down posture of the anthropoid fetus during pregnancy, are primarily focused on anatomic-functional changes that predispose to brain enlargement.
No single theory can completely account for human brain evolution. Multiple selective pressures in combination seems to have been involved.[71] Synthetic theories have been proposed,[72] but have not clearly explained reasons for the uniqueness of the human brain. Puzzlingly, brain enlargement has been found to have occurred independently in different primate lineages,[73] but only human lineage ended up with an exceptional brain capacity. Fetal head-down posture may be an explanation of this conundrum because Homo sapiens is the only primate obligatory biped with upright posture.
See also
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Further reading
- Falk D (2011). The Fossil Chronicles: How Two Controversial Discoveries Changed Our View of Human Evolution. University of California Press. ISBN 978-0-520-26670-4.
- Raichlen DA, Polk JD (January 2013). "Linking brains and brawn: exercise and the evolution of human neurobiology". Proceedings. Biological Sciences. 280 (1750): 20122250. PMID 23173208.
- Striedter GF (2005). Principles of Brain Evolution. Sinauer Associates.
- Eccles JC (1989). Evolution of the Brain. Routledge.