EMR3
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| Identifiers | |||
Gene ontology | |||
| Molecular function | |||
| Cellular component | |||
| Biological process | |||
| Sources:Amigo / QuickGO | |||
Ensembl |
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| UniProt |
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| RefSeq (mRNA) |
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| RefSeq (protein) |
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| Location (UCSC) | Chr 19: 14.62 – 14.69 Mb | n/a | |||||||
| PubMed search | [2] | n/a | |||||||
| View/Edit Human | |||
EGF-like module-containing mucin-like hormone receptor-like 3 is a
Adhesion GPCRs are characterized by an extended extracellular region often possessing N-terminal protein modules that is linked to a TM7 region via a domain known as the GPCR-Autoproteolysis INducing (GAIN) domain.[7]EMR3 expression is restricted to monocytes/macrophages, myeloid dendritic cells, and mature granulocytes in human.[8] Transcription of the EMR3 gene results in two alternative spliced forms: a surface protein with extracellular, 7TM, and intracellular domains as well as a truncated soluble form of only the extracellular domain.[9] Mice, next to Emr2, lack the Emr3 gene.[10]
Function
The protein may play a role in
myeloid-myeloid interactions during immune and inflammatory responses.[11]
Ligands
A potential ligand of EMR3 likely is expressed on human macrophage and activated neutrophils.[9]
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000131355 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- PMID 11279179.
- PMID 25713288.
- ISBN 978-1-4419-7912-4.
- S2CID 6958640.
- PMID 22333914.
- S2CID 37679823.
- ^ PMID 11279179.
- S2CID 16254868.
- ^ "Entrez Gene: EMR3 egf-like module containing, mucin-like, hormone receptor-like 3".