GPR116

ADGRF5
Identifiers
Gene ontology
Molecular function	G protein-coupled receptor activity; transmembrane signaling receptor activity; signal transducer activity;
Cellular component	integral component of membrane; cell surface; plasma membrane; apical part of cell; cytoplasmic vesicle; membrane;
Biological process	surfactant homeostasis; negative regulation of macrophage activation; G protein-coupled receptor signaling pathway; cell surface receptor signaling pathway; energy reserve metabolic process; regulation of lipid metabolic process; fat cell differentiation; positive regulation of phospholipid biosynthetic process; glucose homeostasis; signal transduction; glomerular filtration; erythrocyte development; pharyngeal arch artery morphogenesis;
	Sources:Amigo / QuickGO

Ensembl


ENSG00000069122


ENSMUSG00000056492

UniProt


Q8IZF2


G5E8Q8

RefSeq (mRNA)


NM_001098518 NM_015234


NM_001081178 NM_001357332

RefSeq (protein)


NP_001091988 NP_056049

NP_001074647 NP_001344261 NP_001391458 NP_001391459 NP_001391465
NP_001391470 NP_001391475 NP_001391477

Location (UCSC)

Chr 6: 46.85 – 46.95 Mb

Chr 17: 43.67 – 43.77 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Probable G-protein coupled receptor 116 is a

lung surfactant homeostasis.^[8]^[9]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000069122 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000056492 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
ISBN 978-1-4419-7912-4. {{cite book}}: |first= has generic name (help)CS1 maint: multiple names: authors list (link
)

S2CID 7449692
.

^ "Entrez Gene: GPR116 G protein-coupled receptor 116".

PMID 23684610
.

PMID 23922714
.

Further reading

Vassilatis DK, Hohmann JG, Zeng H, Li F, Ranchalis JE, Mortrud MT, Brown A, Rodriguez SS, Weller JR, Wright AC, Bergmann JE, Gaitanaris GA (Apr 2003). "The G protein-coupled receptor repertoires of human and mouse". Proceedings of the National Academy of Sciences of the United States of America. 100 (8): 4903–8.
PMID 12679517
.

Bjarnadóttir TK, Fredriksson R, Höglund PJ, Gloriam DE, Lagerström MC, Schiöth HB (Jul 2004). "The human and mouse repertoire of the adhesion family of G-protein-coupled receptors". Genomics. 84 (1): 23–33.
PMID 15203201
.

Wiemann S, Arlt D, Huber W, Wellenreuther R, Schleeger S, Mehrle A, Bechtel S, Sauermann M, Korf U, Pepperkok R, Sültmann H, Poustka A (Oct 2004). "From ORFeome to biology: a functional genomics pipeline". Genome Research. 14 (10B): 2136–44.
PMID 15489336
.

v
t
e
Cell surface receptor: G protein-coupled receptors
Class A: Rhodopsin-like
Neurotransmitter
Adrenergic

α1 (A

B

D)

α2 (A

B

C)

β1

β2

β3

Purinergic

Adenosine (A1

A2A

A2B

A3)

P2Y (1

2

4

5

6

8

9

10

11

12

13

14)

Serotonin

(all but 5-HT3) 5-HT1 (A

B

D

E

F)

5-HT2 (A

B

C)

5-HT (4

5A

6

7)

Other

Acetylcholine (M1

M2

M3

M4

M5)

Dopamine
D1

D2

D3

D4

D5

GHB receptor

Histamine
H1

H2

H3

H4

Melatonin (1A

1B

1C)

TAAR (1

2

5

6

8

9)

Metabolites and
signaling molecules
Eicosanoid

CysLT (1

2)

LTB4
1

2

FPRL1

OXE

Prostaglandin
DP (1

1

2

3

4), FP

Prostacyclin

Thromboxane

Other

Bile acid

CB1

18

55

119))

EBI2

Estrogen

Free fatty acid (1

2

3

4)

Hydroxycarboxylic acids
1

2

3

Lysophosphatidic acid (1

2

3

4

5

6)

Lysophospholipid (1

2

3

4

5

6

7

8)

Oxoglutarate

PAF

Sphingosine-1-phosphate (1

2

3

4

5)

Succinate

Peptide
Neuropeptide

B/W (1

2)

FF (1

2)

S

Y (1

2

4

5)

Neuromedin (B

U (1

2))

Neurotensin (1

2)

Other

Anaphylatoxin (C3a

C5a (1

2))

Angiotensin (1

2)

Apelin

Bombesin
BRS3

GRPR

NMBR)

Bradykinin (B1

B2)

Chemokine

Cholecystokinin (A

B)

Endothelin
A

B

Formyl peptide (1

2

3)

FSH

Galanin (1

2

3)

Gonadotropin-releasing hormone (1

2)

Ghrelin

Kisspeptin

Luteinizing hormone/choriogonadotropin

MAS (1

1L

D

E

F

G

X1

X2

X3

X4)

Melanocortin (1

2

3

4

5)

MCHR (1

2)

Motilin

Opioid (Delta

Kappa

Mu

Nociceptin & Zeta, but not Sigma)

Orexin (1

2)

Oxytocin

Prokineticin (1

2)

Prolactin-releasing peptide

Relaxin (1

2

3

4)

Somatostatin (1

2

3

4

5)

Tachykinin (1

2

3)

Thyrotropin

Thyrotropin-releasing hormone

Urotensin-II

1A

1B

2
)

Miscellaneous
Taste, bitter

TAS2R
1

3

4

5

7

8

9

10

13

14

16

19

20

30

31

38

39

40

41

42

43

45

46

50

60

Vomeronasal receptor type 1

Orphan

GPR (1

3

4

6

12

15

17

18

19

20

21

22

23

25

26

27

31

32

33

34

35

37

39

42

44

45

50

52

55

61

62

63

65

68

75

78

81

82

83

84

85

87

88

92

101

103

109A

109B

119

120

132

135

137B

139

141

142

146

148

149

150

151

152

153

160

161

162

171

173

174

176

177

182

183)

Other

Adrenomedullin

Olfactory

Opsin (3

4

5

1LW

1MW

1SW

RGR

RRH)

1

2

3

4)

SREB (1

2

3)

Class B: Secretin-like
Adhesion

ADGRB
Brain-specific angiogenesis inhibitor
1

2

3

ADGRC
Cadherin
1

2

3

ADGRE
EMR
1

2

3

CD97

ADGRG
1

2

3

4

5

6

7

ADGRL
Latrophilin

1

2

3

ELTD1

Orphan

GPR (56

64

97

98

110

111

112

113

114

115

116

123

124

125

126

128

133

143

144

155

157)

Other

Calcitonin

CALCRL

Corticotropin-releasing hormone (1

2)

Glucagon (GR

GIPR

GLP1R

GLP2R)

Growth-hormone-releasing hormone

PACAPR1

GPR

Methuselah-like proteins

Parathyroid hormone (1

2)

Secretin

Vasoactive intestinal peptide (1

2)

Class C: Metabotropic glutamate / pheromone
Taste, sweet

TAS1R
1

2

3

Vomeronasal receptor, type 2

Other

Calcium-sensing receptor

GABA_B (1

2)

Glutamate receptor (Metabotropic glutamate (1

2

3

4

5

6

7

8))

GPRC6A

GPR (156

158

179)

RAIG (1

2

3

4)

Class F: Frizzled & Smoothened
Frizzled

1

2

3

4

5

6

7

8

9

10
)

Smoothened

Smoothened

transmembrane receptor-related article is a stub. You can help Wikipedia by expanding it.
v
t
e

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000069122 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000056492 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[5] ISBN 978-1-4419-7912-4. {{cite book}}: |first= has generic name (help)CS1 maint: multiple names: authors list (link
)

[pmid12435584-6] S2CID 7449692
.

[entrez-7] "Entrez Gene: GPR116 G protein-coupled receptor 116".

[8] PMID 23684610
.

[9] PMID 23922714
.

[3]

[4]

[8]

[9]