Retinal G protein coupled receptor
| RGR | |||
|---|---|---|---|
| Identifiers | |||
Gene ontology | |||
| Molecular function | |||
| Cellular component | |||
| Biological process | |||
| Sources:Amigo / QuickGO | |||
Ensembl | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| UniProt | |||||||||
| RefSeq (mRNA) | |||||||||
| RefSeq (protein) | |||||||||
| Location (UCSC) | Chr 10: 84.23 – 84.26 Mb | Chr 14: 36.76 – 36.77 Mb | |||||||
| PubMed search | [3] | [4] | |||||||
| View/Edit Human | View/Edit Mouse |
RPE-retinal G protein-coupled receptor also known as RGR-opsin is a
GPCR. Like other opsins which bind retinaldehyde, it contains a conserved lysine residue in the seventh transmembrane domain.[7][8] RGR-opsin comes in different isoforms produced by alternative splicing.[6]
Function
RGR-opsin preferentially binds all-trans-retinal,Müller cells.[7]
Phylogeny
The RGR-opsins are restricted to the
The phylogenetic relationship of the RGR-opsins to the other opsins
-
Phylogenetic reconstruction of the opsins. The outgroup contains other G protein-coupled receptors. The frame highlights the tetraopsins, which are expanded in the next image. -
Phylogenetic reconstruction of the tetraopsins. The outgroup contains other G protein-coupled receptors including the other opsins. The frame highlights the chromopsins, which are expanded in the next image. -
Phylogenetic reconstruction of the chromopsins. The outgroup contains other G protein-coupled receptors including the other opsins. The frame highlights the RGR-opsins.
In the
cnidarians. The branches to the clades have pie charts, which give support values for the branches. The values are from right to left SH-aLRT/aBayes/UFBoot. The branches are considered supported when SH-aLRT ≥ 80%, aBayes ≥ 0.95, and UFBoot ≥ 95%. If a support value is above its threshold the pie chart is black otherwise gray.[10]
Clinical significance
RGR-opsin may be associated with autosomal recessive and autosomal dominant retinitis pigmentosa (arRP and adRP, respectively).[14][6]
Interactions
RGR-opsin has been shown to
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000148604 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000021804 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- S2CID 6086858.
- ^ a b c "Entrez Gene: RGR retinal G protein coupled receptor".
- ^ PMID 8258527.
- ^ PMID 7947717.
- PMID 10037690.
- ^ PMID 35954284..
Material was copied and adapted from this source, which is available under a Creative Commons Attribution 4.0 International License - ^ PMID 27797948.
- PMID 22012981.
- PMID 26154478.
- S2CID 35176366.
- S2CID 4427026.
Further reading
- Jiang M, Shen D, Tao L, Pandey S, Heller K, Fong HK (Apr 1995). "Alternative splicing in human retinal mRNA transcripts of an opsin-related protein". Experimental Eye Research. 60 (4): 401–6. PMID 7789419.
- Shen D, Jiang M, Hao W, Tao L, Salazar M, Fong HK (Nov 1994). "A human opsin-related gene that encodes a retinaldehyde-binding protein". Biochemistry. 33 (44): 13117–25. PMID 7947717.
- Chen P, Lee TD, Fong HK (Jun 2001). "Interaction of 11-cis-retinol dehydrogenase with the chromophore of retinal g protein-coupled receptor opsin". The Journal of Biological Chemistry. 276 (24): 21098–104. PMID 11274198.
- Yang M, Fong HK (Feb 2002). "Synthesis of the all-trans-retinal chromophore of retinal G protein-coupled receptor opsin in cultured pigment epithelial cells". The Journal of Biological Chemistry. 277 (5): 3318–24. PMID 11723126.
- Bellingham J, Wells DJ, Foster RG (Jan 2003). "In silico characterisation and chromosomal localisation of human RRH (peropsin)--implications for opsin evolution". BMC Genomics. 4 (1): 3. PMID 12542842.
- Tarttelin EE, Bellingham J, Bibb LC, Foster RG, Hankins MW, Gregory-Evans K, Gregory-Evans CY, Wells DJ, Lucas RJ (Mar 2003). "Expression of opsin genes early in ocular development of humans and mice". Experimental Eye Research. 76 (3): 393–6. PMID 12573668.
- Bernal S, Calaf M, Garcia-Hoyos M, Garcia-Sandoval B, Rosell J, Adan A, Ayuso C, Baiget M (Jul 2003). "Study of the involvement of the RGR, CRPB1, and CRB1 genes in the pathogenesis of autosomal recessive retinitis pigmentosa". Journal of Medical Genetics. 40 (7): 89e–89. PMID 12843338.
- Zhu L, Imanishi Y, Filipek S, Alekseev A, Jastrzebska B, Sun W, Saperstein DA, Palczewski K (Aug 2006). "Autosomal recessive retinitis pigmentosa and E150K mutation in the opsin gene". The Journal of Biological Chemistry. 281 (31): 22289–98. PMID 16737970.
- Lin MY, Kochounian H, Moore RE, Lee TD, Rao N, Fong HK (2007). "Deposition of exon-skipping splice isoform of human retinal G protein-coupled receptor from retinal pigment epithelium into Bruch's membrane". Molecular Vision. 13: 1203–14. PMID 17679941.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.